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protein coding gene - swf1 (SPBC13G1.07) - palmitoyltransferase Swf1

Gene summary

Standard name
swf1
Systematic ID
SPBC13G1.07
Product
palmitoyltransferase Swf1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60069
ORFeome ID
43/43G02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3737549..3738937 forward strand

Annotation

GO biological process

GO:0006612 - protein targeting to membrane

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO:0005794 - Golgi apparatus

References:

GO molecular function

GO:0019706 - protein-cysteine S-palmitoyltransferase activity

References:

Modification

MOD:00595 - monomannosylated residue

References:

Protein features

PBO:0111782 - zf-DHHC type

PBO:0111743 - zinc finger protein

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000023 - protein level constant

References:

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01529DHHCPalmitoyltrfase_DHHCPfam
PS50216DHHCPROSITE profiles
PTHR22883PFA4/ZDH16/20/ERF2-likePANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.
Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597
PMID:36650056 - Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe .
Pham TV et al. Life Sci Alliance 2023 Apr;6(4)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101