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protein coding gene - ykt6 (SPBC13G1.11) - Golgi and vacuolar membrane v-SNARE Ykt6

Gene summary

Standard name
ykt6
Systematic ID
SPBC13G1.11
Product
Golgi and vacuolar membrane v-SNARE Ykt6
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60073
ORFeome ID
07/07D03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3750124..3751325 forward strand

Annotation

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

References:

GO:0006886 - intracellular protein transport

References:

GO:0061025 - membrane fusion

References:

GO cellular component

GO:0012505 - endomembrane system

References:

GO:0005794 - Golgi apparatus

References:

GO:0031201 - SNARE complex

References:

GO molecular function

GO:0005484 - SNAP receptor activity

References:

Modification

MOD:00114 - L-cysteine methyl ester

References:

MOD:00595 - mannosylated residue

References:

MOD:00006 - N-glycosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00111 - S-farnesyl-L-cysteine

References:

MOD:00115 - S-palmitoyl-L-cysteine

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111768 - SNARE

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00957SynaptobrevinV_SNARE_CCPFAM
PF13774LonginLongin_domPFAM
cd14824LonginLongin_domCDD
cd15867R-SNARE_YKT6R-SNARE_YKT6CDD
PS00417SYNAPTOBREVINSynaptobrevin-likePROSITE_PATTERNS
PS50892V_SNAREV_SNARE_CCPROSITE_PROFILES
PS50859LONGINLongin_domPROSITE_PROFILES
SM01270Longin_2Longin_domSMART
PR00219SYNAPTOBREVNSynaptobrevin-likePRINTS
G3DSA:1.20.5.110:FF:000020FUNFAM
SSF64356SNARE-likeLongin-like_dom_sfSUPERFAMILY
SSF58038SNARE fusion complexSUPERFAMILY
G3DSA:1.20.5.110GENE3D
G3DSA:3.30.450.50Longin domainGENE3D
PTHR45806SYNAPTOBREVIN HOMOLOG YKT6PANTHER

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
Nakase Y et al. Genetics 2006 Jun;173(2):569-78
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33788833 - Analysis of the SNARE Stx8 recycling reveals that the retromer-sorting motif has undergone evolutionary divergence.
Yanguas F et al. PLoS Genet 2021 Mar;17(3):e1009463
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000051 - S. pombe keyword mapping
PMID:16483310 - Genetic and functional interaction between Ryh1 and Ypt3: two Rab GTPases that function in S. pombe secretory pathway.
He Y et al. Genes Cells 2006 Mar;11(3):207-21
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:20623139 - Isolation of a fission yeast mutant that is sensitive to valproic acid and defective in the gene encoding Ric1, a putative component of Ypt/Rab-specific GEF for Ryh1 GTPase.
Ma Y et al. Mol Genet Genomics 2010 Sep;284(3):161-71
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105