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protein coding gene - tfb2 (SPBC13G1.13) - transcription factor TFIIH complex subunit Tfb2

Gene summary

Standard name
tfb2
Systematic ID
SPBC13G1.13
Product
transcription factor TFIIH complex subunit Tfb2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC31F10.01
UniProt ID
P87303
ORFeome ID
44/44D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3753900..3755717 forward strand

Annotation

Disease association

MONDO:0980987 - xeroderma pigmentosum, complementation group J

References:

GO biological process

GO:0006289 - nucleotide-excision repair

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0000112 - nucleotide-excision repair factor 3 complex

References:

GO:0000439 - transcription factor TFIIH core complex

References:

GO:0005675 - transcription factor TFIIH holo complex

References:

GO molecular function

GO:0001671 - ATPase activator activity

References:

GO:0003690 - double-stranded DNA binding

References:

GO:0016251 - RNA polymerase II general transcription initiation factor activity

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF18307Tfb2_CTfb2_CPFAM
PF03849Tfb2TFIIH_p52/Tfb2PFAM
G3DSA:3.30.70.2610:FF:000001FUNFAM
G3DSA:3.30.70.2610GENE3D
PTHR13152TFIIH, POLYPEPTIDE 4TFIIH_p52/Tfb2PANTHER
TIGR00625tfb2TFIIH_p52/Tfb2NCBIFAM

Orthologs

References / Literature

PMID:8303296 - RNA polymerase II initiation factor interactions and transcription start site selection.
Li Y et al. Science 1994 Feb 11;263(5148):805-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22344694 - The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.
Calvo IA et al. Nucleic Acids Res 2012 Jun;40(11):4816-24
PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.
Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
GO_REF:0000002 - Comments
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.
Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:14534314 - Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.
Spahr H et al. J Biol Chem 2003 Dec 19;278(51):51301-6