protein coding gene - cut3 (SPBC146.03c) - condensin complex SMC subunit Smc4

Gene summary

Standard name

cut3

Systematic ID

SPBC146.03c

Product

condensin complex SMC subunit Smc4

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

smc4

UniProt ID

P41004

ORFeome ID

34/34A12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1002263..1006523 reverse strand

Annotation

Protein features

Orthologs

• SMC4 (HGNC:14013) Homo sapiens
• cut3 (SJAG_00871) Schizosaccharomyces japonicus
• SMC4 (YLR086W) Saccharomyces cerevisiae

References / Literature

PMID:15148393 - Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin.

Chen ES et al. Proc Natl Acad Sci U S A 2004 May 25;101(21):8078-83

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.

Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31

PMID:40132111 - A fission yeast CENP-B homologue Abp1 prevents RNAi-mediated heterochromatin formation at ribosomal DNA repeats.

Tsunemine S et al. Genetics 2025 Mar 25;

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:19910488 - Centromeric localization of dispersed Pol III genes in fission yeast.

Iwasaki O et al. Mol Biol Cell 2010 Jan 15;21(2):254-65

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898

PMID:20709788 - Ccq1p and the condensin proteins Cut3p and Cut14p prevent telomere entanglements in the fission yeast Schizosaccharomyces pombe.

Motwani T et al. Eukaryot Cell 2010 Oct;9(10):1612-21

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:37820734 - Establishment of dsDNA-dsDNA interactions by the condensin complex.

Tang M et al. Mol Cell 2023 Nov 02;83(21):3787-3800.e9

PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.

Aono N et al. Nature 2002 May 09;417(6885):197-202

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:25392932 - RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.

Legros P et al. PLoS Genet 2014 Nov;10(11):e1004794

GO_REF:0000002 - Comments

PMID:26704981 - Involvement of condensin-directed gene associations in the organization and regulation of chromosome territories during the cell cycle.

Iwasaki O et al. Nucleic Acids Res 2016 May 05;44(8):3618-28

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26869222 - Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.

Takemoto A et al. J Cell Sci 2016 Mar 15;129(6):1250-9

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:29735745 - Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.

Schiklenk C et al. J Cell Biol 2018 Jul 02;217(7):2383-2401

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23084836 - Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation.

Tanaka A et al. Mol Cell 2012 Nov 30;48(4):532-46

PMID:26832414 - Condensin Promotes Position Effects within Tandem DNA Repeats via the RITS Complex.

He H et al. Cell Rep 2016 Feb 09;14(5):1018-1024

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:24362309 - A genetic screen for functional partners of condensin in fission yeast.

Robellet X et al. G3 (Bethesda) 2014 Feb 19;4(2):373-81

PMID:26257282 - Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.

Iwasaki O et al. Mol Cell 2015 Sep 03;59(5):755-67

PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.

Zemlianski V et al. J Cell Sci 2024 May 23;

PMID:35320724 - Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase.

Vijayakumari D et al. Cell Rep 2022 Mar 22;38(12):110554

PMID:10485849 - Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4.

Sutani T et al. Genes Dev 1999 Sep 01;13(17):2271-83

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:28882993 - The condensin complex is a mechanochemical motor that translocates along DNA.

Terakawa T et al. Science 2017 Nov 03;358(6363):672-676

PMID:30914423 - Isolation of Fission Yeast Condensin Temperature-Sensitive Mutants with Single Amino Acid Substitutions Targeted to Hinge Domain.

Xu X et al. G3 (Bethesda) 2019 May 07;9(5):1777-1783

PMID:27266525 - Nucleosome eviction in mitosis assists condensin loading and chromosome condensation.

Toselli-Mollereau E et al. EMBO J 2016 Jul 15;35(14):1565-81

PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.

Nakazawa N et al. J Cell Sci 2011 Jun 01;124(Pt 11):1795-807

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.

Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:23263988 - Quantitative analysis of chromosome condensation in fission yeast.

Petrova B et al. Mol Cell Biol 2013 Mar;33(5):984-98

PMID:31615333 - Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.

Nakazawa N et al. Open Biol 2019 Oct 31;9(10):190125

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:26204128 - Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation.

Sutani T et al. Nat Commun 2015 Jul 23;6:7815

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415

PMID:9285594 - DNA renaturation activity of the SMC complex implicated in chromosome condensation.

Sutani T et al. Nature 1997 Aug 21;388(6644):798-801

PMID:25764183 - Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.

Xu X et al. PLoS One 2015;10(3):e0119347

PMID:15161942 - The nucleolus is involved in mRNA export from the nucleus in fission yeast.

Ideue T et al. J Cell Sci 2004 Jun 15;117(Pt 14):2887-95

PMID:33771877 - RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.

Rivosecchi J et al. Life Sci Alliance 2021 Jun;4(6)

PMID:22645654 - Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Akai Y et al. Open Biol 2011 Dec;1(4):110023

PMID:7957061 - Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.

Saka Y et al. EMBO J 1994 Oct 17;13(20):4938-52

PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

Hirano T et al. EMBO J 1986 Nov;5(11):2973-9

PMID:21633354 - Condensin association with histone H2A shapes mitotic chromosomes.

Tada K et al. Nature 2011 Jun 01;474(7352):477-83

PMID:25520186 - ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding.

Akai Y et al. Open Biol 2014 Dec;4(12)

PMID:9740803 - Mutations in fission yeast Cut15, an importin alpha homolog, lead to mitotic progression without chromosome condensation.

Matsusaka T et al. Curr Biol 1998 Sep 10;8(18):1031-4