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protein coding gene - fan1 (SPBC146.06c) - DNA repair protein Fan1

Gene summary

Standard name
fan1
Systematic ID
SPBC146.06c
Product
DNA repair protein Fan1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y804
ORFeome ID
27/27H10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1010348..1013105 reverse strand

Annotation

PBO:0012851 - 3.1.4.1

Disease association

MONDO:0013898 - karyomegalic interstitial nephritis

References:

GO biological process

GO:0000724 - double-strand break repair via homologous recombination

References:

GO:0036297 - interstrand cross-link repair

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GO:0036298 - recombinational interstrand cross-link repair

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GO cellular component

GO:0005634 - nucleus

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GO molecular function

GO:0008409 - 5'-3' exonuclease activity

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GO:0017108 - 5'-flap endonuclease activity

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GO:0070336 - flap-structured DNA binding

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GO:0004528 - phosphodiesterase I activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0006347 - sensitive to mechlorethamine

References:

Genotypes:

FYPO:0000970 - sensitive to mitomycin C

References:

Genotypes:

FYPO:0000268 - sensitive to UV during vegetative growth

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Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

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Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

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Genotypes:

FYPO:0006348 - normal growth on mechlorethamine

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0005032 - normal mutation rate

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000102 - sensitive to cisplatin

References:

Genotypes:

FYPO:0007330 - sensitive to formaldehyde

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Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0000970 - sensitive to mitomycin C

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF21170FAN1_TPRFAN1-like_TPRPFAM
PF08774VRR_NUCVRR_NUCPFAM
PF21315FAN1_HTHFAN1-like_WHPFAM
cd22326FAN1-likeFAN1-like_eukCDD
SM00990VRR_NUC_a_2VRR_NUCSMART
G3DSA:3.40.1350.10:FF:000009FUNFAM
G3DSA:3.40.1350.10tRNA_endonuc-like_dom_sfGENE3D
PTHR15749FANCONI-ASSOCIATED NUCLEASE 1Fan1-likePANTHER

Orthologs

References / Literature

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31563844 - The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stability.
Sparks JL et al. DNA Repair (Amst) 2019 Nov;83:102720
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605
PMID:25319828 - Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.
Gwon GH et al. Genes Dev 2014 Oct 15;28(20):2276-90
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.
Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.
Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105