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protein coding gene - meu17 (SPBC14C8.05c) - glucan alpha-1,4-glucosidase

Gene summary

Standard name
meu17
Systematic ID
SPBC14C8.05c
Product
glucan alpha-1,4-glucosidase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60087
ORFeome ID
21/21A04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2211798..2213372 reverse strand

Annotation

PBO:0003957 - 3.2.1.3

GO biological process

GO:0005980 - glycogen catabolic process

References:

GO cellular component

GO:1902716 - cell cortex of growing cell tip

References:

GO:0009986 - cell surface

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GO:0000935 - division septum

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GO:0005783 - endoplasmic reticulum

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GO:0000324 - fungal-type vacuole

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GO:0005794 - Golgi apparatus

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GO:0005628 - prospore membrane

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GO molecular function

GO:0004339 - glucan 1,4-alpha-glucosidase activity

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Modification

MOD:00006 - N-glycosylated residue

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MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0001367 - normal cytokinesis

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Genotypes:

FYPO:0005970 - normal growth on magnesium chloride

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0010039 - abolished protein glycosylation during vegetative growth

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Genotypes:

FYPO:0006220 - abolished protein localization to septum

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0002937 - decreased pre-mRNA level

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Genotypes:

FYPO:0001911 - decreased protein glycosylation during vegetative growth

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Genotypes:

FYPO:0002871 - decreased protein localization to growing cell tip

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Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

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Genotypes:

FYPO:0003328 - misoriented interphase microtubules

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Genotypes:

FYPO:0001686 - normal growth on carbendazim

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Genotypes:

FYPO:0005970 - normal growth on magnesium chloride

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Genotypes:

FYPO:0000964 - normal growth on thiabendazole

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Genotypes:

FYPO:0003702 - normal microtubule cytoskeleton morphology during vegetative growth

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Genotypes:

FYPO:0003657 - protein mislocalized to endoplasmic reticulum during vegetative growth

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001701 - sensitive to bortezomib

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00723Glyco_hydro_15GH15-likePfam
PR00736GLHYDRLASE15GlucoamylasePRINTS
G3DSA:1.50.10.10:FF:000018CATH-FunFam
G3DSA:1.50.10.106hp_glycosidase-like_sfCATH-Gene3D
SSF482086-hairpin_glycosidase_sfSUPERFAMILY
PTHR31616PANTHER
Signal PeptideDeepTMHMM-Signal-Peptide

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27172183 - Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.
Larson A et al. G3 (Bethesda) 2016 Jun 01;6(6):1513-23
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.
Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626
PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:11376151 - Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.
Watanabe T et al. Nucleic Acids Res 2001 Jun 01;29(11):2327-37
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000051 - S. pombe keyword mapping
PMID:41203586 - Identification of an ERGIC-Like Compartment in Fission Yeast: Emp43 Functions as a Lectin-Like Cargo Receptor for Glycosylated Proteins.
Imamura I et al. Mol Microbiol 2025 Nov 07;
GO_REF:0000033 - Annotation inferences using phylogenetic trees