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protein coding gene - fmd1 (SPBC1539.07c) - glutathione-dependent formaldehyde dehydrogenase

Gene summary

Standard name
fmd1
Systematic ID
SPBC1539.07c
Product
glutathione-dependent formaldehyde dehydrogenase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P78870
ORFeome ID
21/21F09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4373541..4375125 reverse strand

Annotation

PBO:0004930 - 1.1.1.284

Disease association

MONDO:0007079 - alcohol dependence

References:

MONDO:0030894 - AMED syndrome, digenic

References:

GO biological process

GO:0046294 - formaldehyde catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004022 - alcohol dehydrogenase (NAD+) activity

References:

GO:0106322 - S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity

References:

GO:0106321 - S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity

References:

GO:0080007 - S-nitrosoglutathione reductase (NADH) activity

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0007330 - sensitive to formaldehyde

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

References:

Genotypes:

FYPO:0005776 - normal growth on acetaldehyde

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009067 - sensitive to amorolfine

References:

Genotypes:

FYPO:0007330 - sensitive to formaldehyde

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF08240ADH_NADH-like_NPFAM
PF00107ADH_zinc_NADH-like_CPFAM
cd08300alcohol_DH_class_IIIADH_3CDD
PS00059ADH_ZINCADH_Zn_CSPROSITE_PATTERNS
SM00829PKS_ER_names_modERSMART
G3DSA:3.90.180.10:FF:000001FUNFAM
G3DSA:3.40.50.720:FF:000003FUNFAM
SSF50129GroES-likeGroES-like_sfSUPERFAMILY
SSF51735NAD(P)-binding Rossmann-fold domainsNAD(P)-bd_dom_sfSUPERFAMILY
G3DSA:3.40.50.720GENE3D
G3DSA:3.90.180.10GENE3D
PTHR43880ALCOHOL DEHYDROGENASEPANTHER
TIGR02818adh_III_F_hydeADH_3NCBIFAM

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36095128 - Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.
Anil AT et al. Nucleic Acids Res 2022 Sep 23;50(17):10000-10014
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26645666 - Nitric oxide signaling and its role in oxidative stress response in Schizosaccharomyces pombe.
Astuti RI et al. Nitric Oxide 2016 Jan 30;52:29-40
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.