protein coding gene - mrs6 (SPBC15C4.03) - Rab geranylgeranyltransferase escort protein Mrs6

Gene summary

Standard name: mrs6
Systematic ID: SPBC15C4.03
Product: Rab geranylgeranyltransferase escort protein Mrs6
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: rep1
UniProt ID: O60112
ORFeome ID: 44/44F06
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 2240872..2242475 forward strand

Annotation

Disease association

MONDO:0010557 - choroideremia

References:

PB_REF:0000006

MONDO:0001071 - intellectual disability

References:

PB_REF:0000003

GO biological process

GO:0006612 - protein targeting to membrane

References:

GO_REF:0000033

GO:0016192 - vesicle-mediated transport

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO:0005968 - Rab-protein geranylgeranyltransferase complex

References:

GO_REF:0000033

GO molecular function

GO:0005092 - GDP-dissociation inhibitor activity

References:

GO_REF:0000002

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01149 - sumoylated lysine

References:

PMID:26537787

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

mrs6delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

mrs6delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0001338 - gene name conflict

Protein features

ID	Name	InterPro name	DB name
PF00996	GDI	GDP_dissociation_inhibitor	Pfam
PR00891	RABGDIREP	GDP_dissociation_inhibitor	PRINTS
PR00894	YEASTMRS6P	Mrs6	PRINTS
G3DSA:1.10.405.10:FF:000003			CATH-FunFam
G3DSA:1.10.405.10			CATH-Gene3D
G3DSA:3.30.519.10			CATH-Gene3D
G3DSA:3.50.50.60		FAD/NAD-bd_sf	CATH-Gene3D
SSF51905		FAD/NAD-bd_sf	SUPERFAMILY
PTHR11787		GDP_dissociation_inhibitor	PANTHER
PIRSF037514	Rab_ger_ger_transf_A_fun	Mrs6	PIRSF

Orthologs

CHM (HGNC:1940) Homo sapiens
mrs6 (SJAG_02063) Schizosaccharomyces japonicus
MRS6 (YOR370C) Saccharomyces cerevisiae

References / Literature

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:19486165 - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.: Fang Y et al. Genes Cells 2009 Jun;14(6):759-71
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PB_REF:0000003 - Disease Association Curation
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6