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protein coding gene - alg7 (SPBC15D4.04) - UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Alg7

Gene summary

Standard name
alg7
Systematic ID
SPBC15D4.04
Product
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, Alg7
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
gpt, gpt2
UniProt ID
P42881
ORFeome ID
32/32H04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3018132..3019993 forward strand

Annotation

PBO:0004309 - 2.7.8.15

Complementation

PBO:0011148 - functionally complemented by Chinese Hamster Ovary (CHO) L-G1PT

References:

PBO:0015256 - functionally complemented by hamster Dpagt1

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Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0013883 - congenital myasthenic syndrome 13

References:

MONDO:0011964 - DPAGT1-congenital disorder of glycosylation

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MONDO:0005066 - metabolic disease

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GO biological process

GO:0006488 - dolichol-linked oligosaccharide biosynthetic process

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GO cellular component

GO:0098554 - cytoplasmic side of endoplasmic reticulum membrane

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GO:0005783 - endoplasmic reticulum

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GO:0016020 - membrane

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GO:0043541 - UDP-N-acetylglucosamine transferase complex

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GO molecular function

GO:0003975 - UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

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Modification

MOD:00006 - N-glycosylated residue

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MOD:00046 - O-phospho-L-serine

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MOD:01148 - ubiquitinylated lysine

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003148 - increased UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

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Genotypes:

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00953Glycos_transf_4Glycosyl_transferase_4Pfam
cd06855GT_GPT_eukGPTCDD
PTHR10571GPTPANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000003 - Disease Association Curation
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:9455919 - Aspartic acid 252 and asparagine 185 are essential for activity of lipid N-acetylglucosaminylphosphate transferase.
Scocca JR et al. Glycobiology 1997 Dec;7(8):1181-91
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:7893167 - Asparagine-linked glycosylation in Schizosaccharomyces pombe: functional conservation of the first step in oligosaccharide-lipid assembly.
Zou J et al. Arch Biochem Biophys 1995 Mar 10;317(2):487-96
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323