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protein coding gene - egt1 (SPBC1604.01) - L-histidine N(alpha)-methyltransferase/hercynylcysteine sulfoxide synthase Egt1

Gene summary

Standard name
egt1
Systematic ID
SPBC1604.01
Product
L-histidine N(alpha)-methyltransferase/hercynylcysteine sulfoxide synthase Egt1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC1677.01c, mug158
UniProt ID
O94632
ORFeome ID
28/28C11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3930495..3933264 reverse strand

Annotation

GO biological process

GO:0052699 - ergothioneine biosynthetic process

References:

GO:1903257 - selenoneine biosynthetic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005509 - calcium ion binding

References:

GO:0061686 - hercynylcysteine sulfoxide synthase activity

References:

GO:0052706 - L-histidine N(alpha)-methyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0003523 - increased cellular hercynylselenocysteine level

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003512 - hercynine absent from cell

References:

Genotypes:

FYPO:0003513 - hercynylcysteine sulfoxide absent from cell

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Genotypes:

FYPO:0003514 - hercynylselenocysteine absent from cell

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Genotypes:

FYPO:0003518 - increased cellular hercynine level during vegetative growth

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Genotypes:

FYPO:0003519 - increased cellular hercynylcysteine sulfoxide level during vegetative growth

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Genotypes:

FYPO:0003520 - increased cellular hercynylselenocysteine level during vegetative growth

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Genotypes:

FYPO:0003516 - increased cellular L-ergothioneine level during vegetative growth

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Genotypes:

FYPO:0003517 - increased cellular L-selenoneine level during vegetative growth

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Genotypes:

FYPO:0003511 - L-ergothioneine absent from cell

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Genotypes:

FYPO:0003515 - L-selenoneine absent from cell

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Genotypes:

FYPO:0004295 - multiseptate cell

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Genotypes:

FYPO:0001753 - normal anaerobic cell population growth

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Genotypes:

FYPO:0001437 - normal growth on antimycin A

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Genotypes:

FYPO:0001237 - normal growth on cadmium

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Genotypes:

FYPO:0003506 - normal growth on copper

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0002691 - normal growth on menadione

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Genotypes:

FYPO:0005884 - normal growth on myxothiazol

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Genotypes:

FYPO:0001691 - normal growth on paraquat

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Genotypes:

FYPO:0001239 - normal growth on tert-butyl hydroperoxide

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF03781FGE-sulfataseSUMF_domPfam
PF10017Methyltransf_33MTase_SAM-likePfam
G3DSA:3.40.50.150SAM-dependent_MTases_sfCATH-Gene3D
G3DSA:3.90.1580.10SUMF_sfCATH-Gene3D
SSF53335SAM-dependent_MTases_sfSUPERFAMILY
SSF56436CTDL_foldSUPERFAMILY
PTHR43397EgtD_MethyltrsfPANTHER
TIGR03439methyl_EasFSAM_EasF-likeNCBIFAM

Orthologs

References / Literature

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27005325 - Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.
Pluskal T et al. Genes Cells 2016 Jun;21(6):530-42
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.
Bednor L et al. RNA 2026 Apr 13;
PMID:24828577 - Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
Pluskal T et al. PLoS One 2014;9(5):e97774
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623