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protein coding gene - gpi16 (SPBC1604.15) - GPI-anchor transamidase complex subunit Pig-T, Gpi16

Gene summary

Standard name
gpi16
Systematic ID
SPBC1604.15
Product
GPI-anchor transamidase complex subunit Pig-T, Gpi16
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94380
ORFeome ID
26/26B06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3900976..3904579 reverse strand

Annotation

Disease association

MONDO:0014165 - multiple congenital anomalies-hypotonia-seizures syndrome 3

References:

MONDO:0014166 - paroxysmal nocturnal hemoglobinuria 2

References:

GO biological process

GO:0016255 - attachment of GPI anchor to protein

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0042765 - GPI-anchor transamidase complex

References:

GO:0098553 - lumenal side of endoplasmic reticulum membrane

References:

Modification

MOD:00689 - disulfide crosslinked residues

References:

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04113Gpi16PIG-TPfam
PTHR12959PIG-TPANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideSignal-Peptide-DeepTMHMM

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80