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protein coding gene - tti2 (SPBC1604.17c) - TTT co-chaperone complex subunit Tti2

Gene summary

Standard name
tti2
Systematic ID
SPBC1604.17c
Product
TTT co-chaperone complex subunit Tti2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94729
ORFeome ID
37/37A03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3899936..3901542 forward strand

Annotation

Disease association

MONDO:0014238 - severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome

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GO biological process

GO:0051083 - 'de novo' cotranslational protein folding

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0110078 - TTT Hsp90 cochaperone complex

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GO molecular function

GO:0030674 - protein-macromolecule adaptor activity

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002577 - decreased chromatin binding

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Genotypes:

FYPO:0008121 - decreased protein level in NuA4 complex

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Genotypes:

FYPO:0008120 - decreased protein level in SAGA complex

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0002134 - decreased protein-RNA interaction

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Genotypes:

FYPO:0003827 - decreased ribosomal S6 protein phosphorylation during vegetative growth

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Genotypes:

FYPO:0002876 - decreased transcription

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000847 - increased protein degradation during vegetative growth

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Genotypes:

FYPO:0000780 - increased transcription during vegetative growth

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Genotypes:

FYPO:0001110 - inviable after spore germination, multiple cell divisions, normal morphology

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Genotypes:

FYPO:0002187 - inviable normal volume spheroid vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

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Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

Protein features

IDNameInterPro nameDB name
PF10521Tti2Tti2Pfam
PTHR32226Tti2PANTHER
CoilCOILS

Orthologs

References / Literature

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20801936 - Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.
Takai H et al. Genes Dev 2010 Sep 15;24(18):2019-30
PMID:18076573 - Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
Hayashi T et al. Genes Cells 2007 Dec;12(12):1357-70
PMID:34686329 - The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly.
Toullec D et al. Cell Rep 2021 Oct 19;37(3):109867
PMID:21642955 - Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.
Helmlinger D et al. EMBO J 2011 Jun 03;30(14):2843-52
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31332096 - A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3 ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.
Xu YJ et al. Mol Cell Biol 2019 Oct 15;39(20)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27935167 - CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes in Schizosaccharomyces pombe.
Inoue H et al. Genes Cells 2017 Jan;22(1):59-70
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:31748520 - Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast.
Elías-Villalobos A et al. Nat Commun 2019 Nov 20;10(1):5237