protein coding gene - tea2 (SPBC1604.20c) - kinesin family plus-end directed microtubule motor Tea2

Gene summary

Standard name

tea2

Systematic ID

SPBC1604.20c

Product

kinesin family plus-end directed microtubule motor Tea2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

klp4

UniProt ID

Q1MTQ1

ORFeome ID

26/26D10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3893057..3895256 forward strand

Annotation

Protein features

Orthologs

• KIF22 (HGNC:6391) Homo sapiens
• tea2 (SJAG_00851) Schizosaccharomyces japonicus
• KIP2 (YPL155C) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Takeda K et al. PLoS One 2011;6(7):e22021

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:22137473 - Shaping fission yeast cells by rerouting actin-based transport on microtubules.

Lo Presti L et al. Curr Biol 2011 Dec 20;21(24):2064-9

PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.

Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:12007420 - Tea3p is a cell end marker activating polarized growth in Schizosaccharomyces pombe.

Arellano M et al. Curr Biol 2002 Apr 30;12(9):751-6

PMID:40187481 - Where to grow and where to go.

Kriegler M et al. Fungal Genet Biol 2025 Apr 03;:103983

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:24239120 - Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation.

Syrovatkina V et al. Curr Biol 2013 Dec 02;23(23):2423-9

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:11018050 - Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast.

Browning H et al. J Cell Biol 2000 Oct 02;151(1):15-28

PMID:19686686 - Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.

Fu C et al. Dev Cell 2009 Aug;17(2):257-67

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.

Kelkar M et al. Nat Commun 2015 Oct 07;6:8445

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.

Tanabe T et al. PLoS One 2019;14(4):e0214803

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:36536175 - Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends.

Maan R et al. Nat Cell Biol 2023 Jan;25(1):68-78

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.

Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:15665379 - The EB1 homolog Mal3 stimulates the ATPase of the kinesin Tea2 by recruiting it to the microtubule.

Browning H et al. J Biol Chem 2005 Apr 01;280(13):12299-304

PMID:22696680 - Fission yeast Alp14 is a dose-dependent plus end-tracking microtubule polymerase.

Al-Bassam J et al. Mol Biol Cell 2012 Aug;23(15):2878-90

PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56

PMID:25210736 - Dynamics of cell shape inheritance in fission yeast.

Abenza JF et al. PLoS One 2014;9(9):e106959

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:22144913 - Widespread cotranslational formation of protein complexes.

Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:12034771 - Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton.

Behrens R et al. J Cell Biol 2002 May 27;157(5):783-93

PMID:18059460 - Reconstitution of a microtubule plus-end tracking system in vitro.

Bieling P et al. Nature 2007 Dec 13;450(7172):1100-5

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:36633091 - Microtubule-mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast.

Chacko LA et al. J Cell Sci 2023 Jan 01;136(1)

GO_REF:0000002 - Comments

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:32062975 - Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase.

Wu M et al. J Proteome Res 2020 Apr 03;19(4):1776-1787

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:12789340 - Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips.

Snaith HA et al. Nature 2003 Jun 05;423(6940):647-51

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:20624911 - Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe.

Pöhlmann J et al. Mol Cell Biol 2010 Sep;30(18):4535-47

PMID:21336311 - Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.

Kume K et al. Nat Cell Biol 2011 Mar;13(3):234-42

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.

Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62

PMID:12894167 - Targeted movement of cell end factors in fission yeast.

Browning H et al. Nat Cell Biol 2003 Sep;5(9):812-8

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:25869666 - Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.

Scheffler K et al. J Cell Biol 2015 Apr 13;209(1):47-58

PMID:16141239 - Endocytosis in fission yeast is spatially associated with the actin cytoskeleton during polarised cell growth and cytokinesis.

Gachet Y et al. J Cell Sci 2005 Sep 15;118(Pt 18):4231-42

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:9372443 - Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton.

Arellano M et al. J Cell Sci 1997 Oct;110 ( Pt 20):2547-55

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:15177031 - Tea2p kinesin is involved in spatial microtubule organization by transporting tip1p on microtubules.

Busch KE et al. Dev Cell 2004 Jun;6(6):831-43

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:32723864 - Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.

Zheng F et al. J Biol Chem 2020 Sep 18;295(38):13287-13298

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:20498706 - Tip1/CLIP-170 protein is required for correct chromosome poleward movement in fission yeast.

Goldstone S et al. PLoS One 2010 May 13;5(5):e10634

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:30602572 - Association of mitochondria with microtubules inhibits mitochondrial fission by precluding assembly of the fission protein Dnm1.

Mehta K et al. J Biol Chem 2019 Mar 08;294(10):3385-3396