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protein coding gene - tda1 (SPBC1677.03c) - threonine ammonia-lyase Tda1

Gene summary

Standard name
tda1
Systematic ID
SPBC1677.03c
Product
threonine ammonia-lyase Tda1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94634
ORFeome ID
36/36E02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3935430..3937666 reverse strand

Annotation

PBO:0004730 - 4.3.1.19

GO biological process

GO:1901705 - L-isoleucine biosynthetic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0030170 - pyridoxal phosphate binding

References:

GO:0004794 - threonine deaminase activity

References:

Modification

MOD:00128 - N6-pyridoxal phosphate-L-lysine

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000320 - inviable after spore germination, single cell division, normal cell morphology

References:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00291PALPTrpB-like_PALPPfam
PF00585Thr_dehydrat_CTD_ACT-likePfam
cd01562Thr-dehydCDD
cd04906ACT_ThrD-I_1CDD
cd04907ACT_ThrD-I_2CDD
PS00165DEHYDRATASE_SER_THRSer/Thr_deHydtase_PyrdxlP-BSPROSITE patterns
PS51672ACT_LIKETD_ACT-likePROSITE profiles
G3DSA:3.40.1020.10:FF:000001CATH-FunFam
G3DSA:3.40.50.1100:FF:000008CATH-FunFam
G3DSA:3.40.1020.10TD_ACT-like_sfCATH-Gene3D
G3DSA:3.40.50.1100TrpB-like_PALP_sfCATH-Gene3D
SSF53686TrpB-like_PALP_sfSUPERFAMILY
SSF55021ACT-like_dom_sfSUPERFAMILY
PTHR48078Ser/Thr_DehydratasePANTHER
NF006674ilvANCBIFAM
TIGR01124ilvA_2CtermThr_deHydtase_biosynthNCBIFAM

Orthologs

References / Literature

PMID:4698209 - Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: regulatory properties of threonine deaminase.
McDonald RA et al. J Bacteriol 1973 Apr;114(1):323-31
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
GO_REF:0000002 - Comments
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36