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protein coding gene - ghf3 (SPBC1683.04) - glycosyl hydrolase family 3, Ghf3

Gene summary

Standard name
ghf3
Systematic ID
SPBC1683.04
Product
glycosyl hydrolase family 3, Ghf3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6J6
ORFeome ID
29/29A09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 142412..145393 forward strand

Annotation

GO biological process

GO:0009251 - glucan catabolic process

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GO cellular component

GO:0005829 - cytosol

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GO molecular function

GO:0008422 - beta-glucosidase activity

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Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000022 - shmoo with long tip

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011064 - conserved in fungi

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00933Glyco_hydro_3Glyco_hydro_3_NPfam
PF01915Glyco_hydro_3_CGlyco_hydro_3_CPfam
PF07691PA14PA14_domPfam
PF14310Fn3-likeFn3-likePfam
PS00775GLYCOSYL_HYDROL_F3Glyco_hydro_3_ASPROSITE patterns
PS51820PA14PA14/GLEYAPROSITE profiles
SM00758PA14PA14_domSMART
SM01217Fn3_likeFn3-likeSMART
PR00133GLHYDRLASE3Glyco_hydro_3_NPRINTS
G3DSA:2.60.40.10:FF:000495CATH-FunFam
G3DSA:3.20.20.300:FF:000006CATH-FunFam
G3DSA:2.60.120.260CATH-Gene3D
G3DSA:2.60.40.10Ig-like_foldCATH-Gene3D
G3DSA:3.20.20.300Glyco_hydro_3_N_sfCATH-Gene3D
G3DSA:3.40.50.1700Glyco_hydro_3_C_sfCATH-Gene3D
SSF51445GH_hydrolase_sfSUPERFAMILY
SSF52279Glyco_hydro_3_C_sfSUPERFAMILY
SSF56988SUPERFAMILY
PTHR42715Cellulose_deg_GH3PANTHER

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83