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protein coding gene - mal1 (SPBC1683.07) - maltase alpha-glucosidase Mal1

Gene summary

Standard name
mal1
Systematic ID
SPBC1683.07
Product
maltase alpha-glucosidase Mal1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P6J3
ORFeome ID
35/35H07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 152911..155630 forward strand

Annotation

PBO:0001817 - 3.2.1.20

Catalytic activity attributes

PBO:0017858 - hydrolysis rate of dextrin to glucose is 7.6 (uM min-1 ml-2)

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PBO:0017857 - hydrolysis rate of maltose to glucose is 14.5 (uM min-1 ml-2)

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PBO:0091656 - hydrolysis rate of PNPG to glucose is 20.3 (uM min-1 ml-2)

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PBO:0017859 - hydrolysis rate of soluble starch to glucose is 8.9 (uM min-1 ml-2)

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PBO:0017860 - hydrolysis rate of sucrose to glucose is 3.1 (uM min-1 ml-2)

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GO biological process

GO:0000025 - maltose catabolic process

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GO:0000272 - polysaccharide catabolic process

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GO:0005987 - sucrose catabolic process

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0004558 - alpha-1,4-glucosidase activity

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GO:0033934 - glucan 1,4-alpha-maltotriohydrolase activity

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GO:0004574 - oligo-1,6-glucosidase activity

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GO:0004575 - sucrose alpha-glucosidase activity

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0001175 - normal growth on maltose carbon source

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Genotypes:

FYPO:0009079 - resistance to calcofluor and sodium dodecyl sulfate

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FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0001097 - sensitive to amitrole

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FYPO:0009067 - sensitive to amorolfine

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FYPO:0009069 - sensitive to ciclopirox olamine

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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FYPO:0002328 - sensitive to terbinafine

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FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00128Alpha-amylaseGH13_cat_domPfam
cd11333AmyAc_SI_OligoGlu_DGaseCDD
SM00642AamyGH13_cat_domSMART
G3DSA:2.60.40.1180:FF:000007CATH-FunFam
G3DSA:3.20.20.80:FF:000064CATH-FunFam
G3DSA:3.20.20.80:FF:000087CATH-FunFam
G3DSA:3.90.400.10:FF:000003CATH-FunFam
G3DSA:2.60.40.1180Glyco_hydro_bCATH-Gene3D
G3DSA:3.20.20.80CATH-Gene3D
G3DSA:3.90.400.10O16G_dom_2CATH-Gene3D
SSF51011SUPERFAMILY
SSF51445GH_hydrolase_sfSUPERFAMILY
PTHR10357PANTHER

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16496115 - Studies on inositol-mediated expression of MAL gene encoding maltase and phospholipid biosynthesis in Schizosaccharomyces pombe.
Yao S et al. J Ind Microbiol Biotechnol 2006 Jun;33(6):417-22
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:18556189 - Cloning and overexpression of a maltase gene from Schizosaccharomyces pombe in Escherichia coli and characterization of the recombinant maltase.
Chi Z et al. Mycol Res 2008 Aug;112(Pt 8):983-9
PMID:24224056 - The transcription factors Atf1 and Pcr1 are essential for transcriptional induction of the extracellular maltase Agl1 in fission yeast.
Kato H et al. PLoS One 2013;8(11):e80572
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16914721 - Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.
Rodríguez-Gabriel MA et al. Mol Cell Biol 2006 Sep;26(17):6347-56
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83