protein coding gene - frp1 (SPBC1683.09c) - plasma membrane ferric iron reductase (NADPH) Frp1

Gene summary

Standard name

frp1

Systematic ID

SPBC1683.09c

Product

plasma membrane ferric iron reductase (NADPH) Frp1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q04800

ORFeome ID

35/35C11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 160357..162392 reverse strand

Annotation

Protein features

Orthologs

• CYBB (HGNC:2578) Homo sapiens
• NOX1 (HGNC:7889) Homo sapiens
• NOX3 (HGNC:7890) Homo sapiens
• NOX4 (HGNC:7891) Homo sapiens
• frp1 (SJAG_04743) Schizosaccharomyces japonicus
• AIM14 (YGL160W) Saccharomyces cerevisiae
• FRE2 (YKL220C) Saccharomyces cerevisiae
• FRE6 (YLL051C) Saccharomyces cerevisiae
• FRE8 (YLR047C) Saccharomyces cerevisiae
• FRE1 (YLR214W) Saccharomyces cerevisiae
• FRE4 (YNR060W) Saccharomyces cerevisiae
• FRE7 (YOL152W) Saccharomyces cerevisiae
• FRE3 (YOR381W) Saccharomyces cerevisiae
• FRE5 (YOR384W) Saccharomyces cerevisiae

References / Literature

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PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

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PMID:28882432 - Analysis of ambient pH stress response mediated by iron and copper intake in Schizosaccharomyces pombe.

Higuchi Y et al. J Biosci Bioeng 2018 Jan;125(1):92-96

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:35079912 - Identification and analysis of iron transporters from the fission yeast Schizosaccharomyces pombe.

Ahmad F et al. Arch Microbiol 2022 Jan 26;204(2):152

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

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PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.

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PMID:37772819 - Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase.

Sanchez AM et al. mBio 2023 Sep 29;14(5):e0205623

PMID:41974504 - Nuclear basket subunits Nup211 and Rsm1 influence RNA 3'-processing and transcription termination in fission yeast.

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PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:10593913 - A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe.

Labbé S et al. J Biol Chem 1999 Dec 17;274(51):36252-60

PMID:21511999 - Comparative functional genomics of the fission yeasts.

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PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.

Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8

PMID:19915076 - abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe.

Pouliot B et al. Eukaryot Cell 2010 Jan;9(1):59-73

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S et al. EMBO Rep 2014 Aug;15(8):894-902

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.

Bednor L et al. mBio 2023 Dec 22;:e0306223

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

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PMID:17477863 - Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.

Rustici G et al. Genome Biol 2007;8(5):R73

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.

Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826

PMID:33579781 - Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.

Garg A et al. RNA 2021 Feb 12;27(5):560-70

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

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PMID:39940646 - The Ferroxidase-Permease System for Transport of Iron Across Membranes: From Yeast to Humans.

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PMID:30393157 - Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.

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PMID:37923140 - Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal.

Hati D et al. J Biol Chem 2023 Nov 03;299(12):105419

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

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PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.

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PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

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PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

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PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

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GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

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PMID:35657410 - Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.

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PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

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PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

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PMID:8321236 - The fission yeast ferric reductase gene frp1+ is required for ferric iron uptake and encodes a protein that is homologous to the gp91-phox subunit of the human NADPH phagocyte oxidoreductase.

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PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

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PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

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PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.

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