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protein coding gene - avt5 (SPBC1685.07c) - vacuolar amino acid transmembrane transporter Avt5

Gene summary

Standard name
avt5
Systematic ID
SPBC1685.07c
Product
vacuolar amino acid transmembrane transporter Avt5
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
avt8
UniProt ID
O74327
ORFeome ID
20/20B10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 509491..512849 reverse strand

Annotation

Disease association

MONDO:0030881 - developmental and epileptic encephalopathy 102

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GO biological process

GO:0032975 - amino acid transmembrane import into vacuole

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GO:0090518 - L-arginine transmembrane import into vacuole

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GO:0051938 - L-glutamate import

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GO:0090515 - L-glutamate transmembrane import into vacuole

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GO:0090513 - L-histidine transmembrane import into vacuole

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GO:0090517 - L-lysine transmembrane import into vacuole

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GO:0090516 - L-serine transmembrane import into vacuole

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GO:0090514 - L-tyrosine transmembrane import into vacuole

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GO cellular component

GO:0000329 - fungal-type vacuole membrane

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GO molecular function

GO:0061459 - L-arginine transmembrane transporter activity

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GO:0005313 - L-glutamate transmembrane transporter activity

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GO:0005290 - L-histidine transmembrane transporter activity

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GO:0015189 - L-lysine transmembrane transporter activity

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GO:0015194 - L-serine transmembrane transporter activity

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GO:0005302 - L-tyrosine transmembrane transporter activity

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Modification

MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001592 - decreased arginine import

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Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0001644 - decreased cellular lithium level

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Genotypes:

FYPO:0001060 - decreased glutamate import during vegetative growth

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Genotypes:

FYPO:0001591 - decreased histidine import

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Genotypes:

FYPO:0001590 - decreased lysine import during vegetative growth

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0001595 - decreased serine import

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Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0001068 - decreased tyrosine import

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Genotypes:

FYPO:0003938 - increased cell population growth during glucose starvation

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0001599 - normal asparagine import

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Genotypes:

FYPO:0001598 - normal glutamine import

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0001600 - normal isoleucine import

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Genotypes:

FYPO:0001597 - normal valine import

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0000851 - resistance to osmotic stress

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000852 - resistance to salt stress

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01490Aa_transAA_transpt_TMPfam
PTHR22950PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.
Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20699567 - Vacuolar amino acid transporter Avt5p is responsible for lithium uptake in Schizosaccharomyces pombe.
Iwaki T et al. Biosci Biotechnol Biochem 2010;74(8):1719-21
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.
Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:19778961 - Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.
Mukaiyama H et al. Microbiology (Reading) 2009 Dec;155(Pt 12):3816-3826
PMID:20388511 - Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe.
Chardwiriyapreecha S et al. FEBS Lett 2010 Jun 03;584(11):2339-45
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14