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protein coding gene - klp6 (SPBC1685.15c) - kinesin-8 family plus-end directed microtubule motor Klp6

Gene summary

Standard name
klp6
Systematic ID
SPBC1685.15c
Product
kinesin-8 family plus-end directed microtubule motor Klp6
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
sot2, SPBC649.01c
UniProt ID
O59751
ORFeome ID
28/28E12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 532193..535148 reverse strand

Annotation

GO biological process

GO:1902426 - deactivation of mitotic spindle assembly checkpoint

References:

GO:0007019 - microtubule depolymerization

References:

GO:0007079 - mitotic chromosome movement towards spindle pole

References:

GO:1990942 - mitotic metaphase chromosome recapture

References:

GO:1990758 - mitotic sister chromatid biorientation

References:

GO:0000070 - mitotic sister chromatid segregation

References:

GO:0000022 - mitotic spindle elongation

References:

GO:0061804 - mitotic spindle formation (spindle phase one)

References:

GO:0007052 - mitotic spindle organization

References:

GO:0070462 - plus-end specific microtubule depolymerization

References:

GO:0140210 - protein transport along microtubule to kinetochore

References:

GO cellular component

GO:0055028 - cortical microtubule

References:

GO:0005737 - cytoplasm

References:

GO:1904511 - cytoplasmic microtubule plus-end

References:

GO:0005829 - cytosol

References:

GO:0016938 - kinesin I complex

References:

GO:0000776 - kinetochore

References:

GO:0015630 - microtubule cytoskeleton

References:

GO:0072686 - mitotic spindle

References:

GO:0061673 - mitotic spindle astral microtubule

References:

GO:1990023 - mitotic spindle midzone

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0005634 - nucleus

References:

GO:0005873 - plus-end kinesin complex

References:

GO:1990295 - post-anaphase microtubule array

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0008017 - microtubule binding

References:

GO:0008574 - plus-end-directed microtubule motor activity

References:

GO:0005515 - protein binding

References:

Miscellaneous functional group

PBO:0000205 - nucleocytoplasmic shuttling protein

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0002029 - abnormal cell division, large and small daughter cells

References:

Genotypes:

FYPO:0006040 - abnormal kinetochore microtubule polymerization during mitotic metaphase chromosome recapture

References:

Genotypes:

FYPO:0000030 - abnormal mitotic chromosome congression

References:

Genotypes:

FYPO:0000326 - abnormal mitotic sister chromatid biorientation

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000670 - abnormal mitotic sister chromatid separation

References:

Genotypes:

FYPO:0001894 - abnormal sporulation resulting in formation of ascus with more or fewer than four spores

References:

Genotypes:

FYPO:0003379 - abolished meiosis II

References:

Genotypes:

FYPO:0003327 - curved interphase microtubules

References:

Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

References:

Genotypes:

FYPO:0005682 - decreased microtubule depolymerization during vegetative growth

References:

Genotypes:

FYPO:0005681 - decreased microtubule polymerization

References:

Genotypes:

FYPO:0007196 - decreased mitochondrial fission

References:

Genotypes:

FYPO:0005727 - decreased rate of deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0005364 - decreased rate of kinetochore sliding during chromosome recapture

References:

Genotypes:

FYPO:0006041 - decreased rate of mitotic metaphase chromosome recapture

References:

Genotypes:

FYPO:0005343 - decreased rate of mitotic spindle elongation during anaphase B

References:

Genotypes:

FYPO:0006045 - delayed onset of mitotic sister chromatid biorientation

References:

Genotypes:

FYPO:0004705 - delayed onset of mitotic sister chromatid separation

References:

Genotypes:

FYPO:0005426 - elongated C-shaped vegetative cell with long curved interphase microtubules

References:

Genotypes:

FYPO:0006049 - fluctuating mitotic spindle length

References:

Genotypes:

FYPO:0006039 - incomplete mitotic metaphase chromosome recapture

References:

Genotypes:

FYPO:0007976 - increased duration of interpolar microtubule growth events during anaphase B

References:

Genotypes:

FYPO:0000274 - increased duration of mitotic M phase

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0002059 - inviable cell population

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0004101 - lagging mitotic chromosomes, with complete sister chromatid separation

References:

Genotypes:

FYPO:0007195 - large mitochondria

References:

Genotypes:

FYPO:0004511 - long curved interphase microtubules

References:

Genotypes:

FYPO:0004611 - long interphase microtubules

References:

Genotypes:

FYPO:0007847 - long meiosis I spindle

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0003820 - mitochondria present in decreased numbers during vegetative growth

References:

Genotypes:

FYPO:0000324 - mitotic metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0006171 - mitotic spindle elongation during anaphase A

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0005728 - normal deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0005342 - normal rate of mitotic spindle elongation during anaphase B

References:

Genotypes:

FYPO:0000069 - resistance to thiabendazole

References:

Genotypes:

FYPO:0006084 - sensitive to cold shock

References:

Genotypes:

FYPO:0004395 - short bipolar mitotic spindle during metaphase

References:

Genotypes:

FYPO:0003810 - small fragmented mitochondria present in increased numbers

References:

Genotypes:

FYPO:0007849 - spindle self-assembly during meiosis I

References:

Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

References:

Genotypes:

FYPO:0003241 - unequal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Protein features

PBO:0111914 - kinesin-8 family

PBO:0111913 - Kip3 subfamily

Protein sequence feature

SO:0001528 - nuclear_localization_signal

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000030 - abnormal mitotic chromosome congression

References:

Genotypes:

FYPO:0007128 - abnormal mitotic chromosome movement towards spindle pole

References:

Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0000670 - abnormal mitotic sister chromatid separation

References:

Genotypes:

FYPO:0003779 - abnormal nuclear envelope morphology during mitosis

References:

Genotypes:

FYPO:0000357 - abnormal shmoo morphology

References:

Genotypes:

FYPO:0000121 - abnormal sporulation

References:

Genotypes:

FYPO:0001894 - abnormal sporulation resulting in formation of ascus with more or fewer than four spores

References:

Genotypes:

FYPO:0005726 - abolished deactivation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0003186 - abolished protein localization to mitotic spindle

References:

Genotypes:

FYPO:0001424 - abolished protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0001270 - complete but unequal mitotic sister chromatid segregation

References:

Genotypes:

FYPO:0003327 - curved interphase microtubules

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0006047 - decreased interkinetochore distance before mitotic anaphase

References:

Genotypes:

FYPO:0005682 - decreased microtubule depolymerization during vegetative growth

References:

Genotypes:

FYPO:0005681 - decreased microtubule polymerization

References:

Genotypes:

FYPO:0003189 - decreased protein import into nucleus

References:

Genotypes:

FYPO:0000937 - decreased protein localization to cortical microtubule cytoskeleton during vegetative growth

References:

Genotypes:

FYPO:0002825 - decreased protein localization to mitotic spindle

References:

Genotypes:

FYPO:0003190 - decreased rate of cytoplasmic microtubule depolymerization during vegetative growth

References:

Genotypes:

FYPO:0000903 - decreased rate of microtubule depolymerization during vegetative growth

References:

Genotypes:

FYPO:0006041 - decreased rate of mitotic metaphase chromosome recapture

References:

Genotypes:

FYPO:0004705 - delayed onset of mitotic sister chromatid separation

References:

Genotypes:

FYPO:0003226 - delayed onset of protein localization to mitotic spindle

References:

Genotypes:

FYPO:0006049 - fluctuating mitotic spindle length

References:

Genotypes:

FYPO:0006039 - incomplete mitotic metaphase chromosome recapture

References:

Genotypes:

FYPO:0002638 - increased activation of mitotic spindle assembly checkpoint

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0008008 - increased duration of cytoplasmic microtubule growth events during mitotic interphase

References:

Genotypes:

FYPO:0000274 - increased duration of mitotic M phase

References:

Genotypes:

FYPO:0006180 - increased microtubule polymerization

References:

Genotypes:

FYPO:0001840 - increased minichromosome loss during vegetative growth

References:

Genotypes:

FYPO:0006043 - increased rate of kinetochore sliding during chromosome recapture

References:

Genotypes:

FYPO:0007959 - increased rate of mitotic spindle elongation during prophase

References:

Genotypes:

FYPO:0003227 - interphase microtubules present during mitosis

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0004393 - lagging chromosomes during meiosis I

References:

Genotypes:

FYPO:0004394 - lagging chromosomes during meiosis II

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0004101 - lagging mitotic chromosomes, with complete sister chromatid separation

References:

Genotypes:

FYPO:0004511 - long curved interphase microtubules

References:

Genotypes:

FYPO:0004863 - long curved microtubules

References:

Genotypes:

FYPO:0006044 - long mitotic kinetochore microtubules with kinetochore at tip of nuclear envelope protrusion

References:

Genotypes:

FYPO:0000733 - long mitotic spindle

References:

Genotypes:

FYPO:0004307 - long mitotic spindle during metaphase

References:

Genotypes:

FYPO:0004021 - long polar microtubules

References:

Genotypes:

FYPO:0006518 - loss of viability in G0

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0003969 - mislocalized mitotic spindle

References:

Genotypes:

FYPO:0000324 - mitotic metaphase/anaphase transition delay

References:

Genotypes:

FYPO:0007553 - normal G1 to G0 transition

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0003178 - normal meiotic sister chromatid segregation

References:

Genotypes:

FYPO:0003627 - normal protein localization

References:

Genotypes:

FYPO:0003185 - normal protein localization to microtubule cytoskeleton during mitotic interphase

References:

Genotypes:

FYPO:0003349 - normal protein localization to mitotic spindle midzone during anaphase B

References:

Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0003225 - normal rate of microtubule polymerization during vegetative growth

References:

Genotypes:

FYPO:0005342 - normal rate of mitotic spindle elongation during anaphase B

References:

Genotypes:

FYPO:0007746 - normal spindle elongation during meiotic metaphase I

References:

Genotypes:

FYPO:0003187 - protein mislocalized to astral microtubule during mitosis

References:

Genotypes:

FYPO:0002693 - resistance to diamide

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000069 - resistance to thiabendazole

References:

Genotypes:

FYPO:0001701 - sensitive to bortezomib

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0006084 - sensitive to cold shock

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0006046 - uncentered mitotic chromosome congression

References:

Genotypes:

FYPO:0000678 - unequal homologous chromosome segregation

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

FYPO:0002104 - viable vegetative cell with normal cell shape

References:

Genotypes:

Subunit composition

PBO:0015221 - heteromeric(2)

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00225KinesinKinesin_motor_domPFAM
cd01370KISc_KIP3_likeCDD
PS00411KINESIN_MOTOR_1Kinesin_motor_CSPROSITE_PATTERNS
PS50067KINESIN_MOTOR_2Kinesin_motor_domPROSITE_PROFILES
SM00129kinesin_4Kinesin_motor_domSMART
PR00380KINESINHEAVYKinesin_motor_domPRINTS
G3DSA:3.40.850.10:FF:000090FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
G3DSA:3.40.850.10Kinesin motor domainKinesin_motor_dom_sfGENE3D
PTHR47968CENTROMERE PROTEIN EKinesin-like_famPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:32327557 - Kinesin-14 family proteins and microtubule dynamics define S. pombe mitotic and meiotic spindle assembly, and elongation.
Loncar A et al. J Cell Sci 2020 Jun 08;133(11)
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.
Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:19686686 - Phospho-regulated interaction between kinesin-6 Klp9p and microtubule bundler Ase1p promotes spindle elongation.
Fu C et al. Dev Cell 2009 Aug;17(2):257-67
PMID:27697865 - Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.
Topolski B et al. Mol Cell Biol 2016 Dec 15;36(24):3128-3140
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:25422470 - Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.
Scheffler K et al. Proc Natl Acad Sci U S A 2014 Dec 16;111(50):17899-904
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:33925026 - Dual Impact of a Benzimidazole Resistant β-Tubulin on Microtubule Behavior in Fission Yeast.
Minagawa M et al. Cells 2021 Apr 28;10(5)
PMID:14573463 - Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis.
Li Y et al. Genetics 2003 Oct;165(2):477-88
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16079915 - The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.
Sanchez-Perez I et al. EMBO J 2005 Aug 17;24(16):2931-43
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
GO_REF:0000002 - Comments
PMID:22363481 - S. pombe kinesins-8 promote both nucleation and catastrophe of microtubules.
Erent M et al. PLoS One 2012;7(2):e30738
PMID:31427431 - Kinesin-8 and Dis1/TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation in fission yeast.
Pinder C et al. J Cell Sci 2019 Sep 23;132(18)
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:35293864 - Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B.
Lera-Ramirez M et al. Elife 2022 Mar 16;11
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:12426374 - Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.
Garcia MA et al. EMBO J 2002 Nov 15;21(22):6015-24
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.
Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21664573 - Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.
Meadows JC et al. Dev Cell 2011 Jun 14;20(6):739-50
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:30602572 - Association of mitochondria with microtubules inhibits mitochondrial fission by precluding assembly of the fission protein Dnm1.
Mehta K et al. J Biol Chem 2019 Mar 08;294(10):3385-3396
PMID:34346498 - Loss of kinesin-8 improves the robustness of the self-assembled spindle in Schizosaccharomyces pombe.
Pineda-Santaella A et al. J Cell Sci 2021 Aug 15;134(16)
PMID:24530531 - Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips.
Zheng F et al. FEBS Lett 2014 Mar 18;588(6):859-65
PMID:24239120 - Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation.
Syrovatkina V et al. Curr Biol 2013 Dec 02;23(23):2423-9
PMID:11870212 - Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.
West RR et al. J Cell Sci 2002 Mar 01;115(Pt 5):931-40
PMID:32723864 - Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I.
Zheng F et al. J Biol Chem 2020 Sep 18;295(38):13287-13298
PMID:18799626 - Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics.
Unsworth A et al. Mol Biol Cell 2008 Dec;19(12):5104-15
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:25472718 - Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.
Tang NH et al. J Cell Sci 2015 Jan 15;128(2):354-63
PMID:11739790 - Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast.
West RR et al. Mol Biol Cell 2001 Dec;12(12):3919-32
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:36633091 - Microtubule-mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast.
Chacko LA et al. J Cell Sci 2023 Jan 01;136(1)
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:16824200 - Schizosaccharomyces pombe homolog of Survivin, Bir1p, exhibits a novel dynamic behavior at the spindle mid-zone.
Rajagopalan S et al. Genes Cells 2006 Jul;11(7):815-27
PMID:28513584 - Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast.
Rincon SA et al. Nat Commun 2017 May 17;8:15286
PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Han TX et al. Genome Biol 2010;11(6):R60
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:27146110 - Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast.
Gergely ZR et al. Mol Biol Cell 2016 Nov 07;27(22):3490-3514
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:11967147 - Two kinesin-like Kin I family proteins in fission yeast regulate the establishment of metaphase and the onset of anaphase A.
Garcia MA et al. Curr Biol 2002 Apr 16;12(8):610-21
PMID:15280226 - Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe.
Tange Y et al. Genetics 2004 Jul;167(3):1095-107
PMID:19037096 - Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement.
Grissom PM et al. Mol Biol Cell 2009 Feb;20(3):963-72
PMID:18262494 - Fission yeast dam1-A8 mutant is resistant to and rescued by an anti-microtubule agent.
Griffiths K et al. Biochem Biophys Res Commun 2008 Apr 11;368(3):670-6