protein coding gene - rae1 (SPBC16A3.05c) - RNA export factor Rae1

Gene summary

Standard name

rae1

Systematic ID

SPBC16A3.05c

Product

RNA export factor Rae1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

cut21

UniProt ID

P41838

ORFeome ID

33/33B04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 4288945..4290900 forward strand

Annotation

Protein features

Orthologs

• RAE1 (HGNC:9828) Homo sapiens
• rae1 (SJAG_04379) Schizosaccharomyces japonicus
• GLE2 (YER107C) Saccharomyces cerevisiae

References / Literature

PMID:18023413 - Dss1 associating with the proteasome functions in selective nuclear mRNA export in yeast.

Mannen T et al. Biochem Biophys Res Commun 2008 Jan 25;365(4):664-71

PMID:22936388 - Isolation of a novel rmn1 gene genetically linked to spnab2 with respect to mRNA export in fission yeast.

Cho YS et al. Mol Cells 2012 Sep;34(3):315-21

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:12181330 - Crp79p, like Mex67p, is an auxiliary mRNA export factor in Schizosaccharomyces pombe.

Thakurta AG et al. Mol Biol Cell 2002 Aug;13(8):2571-84

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29424342 - YTH-RNA-binding protein prevents deleterious expression of meiotic proteins by tethering their mRNAs to nuclear foci.

Shichino Y et al. Elife 2018 Feb 09;7

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:22240020 - Characterization of the ptr5+ gene involved in nuclear mRNA export in fission yeast.

Watanabe N et al. Biochem Biophys Res Commun 2012 Feb 03;418(1):62-6

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:9301023 - Advancement through mitosis requires rae1 gene function in fission yeast.

Whalen WA et al. Yeast 1997 Sep 30;13(12):1167-79

PMID:15990877 - Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast.

Thakurta AG et al. EMBO J 2005 Jul 20;24(14):2512-23

PMID:9370289 - The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA.

Bharathi A et al. Gene 1997 Oct 01;198(1-2):251-8

PMID:11073978 - Mex67p of Schizosaccharomyces pombe interacts with Rae1p in mediating mRNA export.

Yoon JH et al. Mol Cell Biol 2000 Dec;20(23):8767-82

PMID:18758733 - The fission yeast homologue of Glel is essential for growth and involved in mRNA export.

Moon D et al. J Microbiol 2008 Aug;46(4):422-8

PMID:7706287 - A mutation in the Schizosaccharomyces pombe rae1 gene causes defects in poly(A)+ RNA export and in the cytoskeleton.

Brown JA et al. J Biol Chem 1995 Mar 31;270(13):7411-9

PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.

Asakawa H et al. Nucleus 2014;5(2):149-62

PMID:15509783 - Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p.

Vanoosthuyse V et al. Mol Cell Biol 2004 Nov;24(22):9786-801

PMID:9372936 - Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.

Yoon JH et al. Mol Cell Biol 1997 Dec;17(12):7047-60

PMID:15094387 - The fission yeast ptr1+ gene involved in nuclear mRNA export encodes a putative ubiquitin ligase.

Andoh T et al. Biochem Biophys Res Commun 2004 May 14;317(4):1138-43

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86

PMID:20231270 - Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

Selvanathan SP et al. J Biol Chem 2010 May 07;285(19):14122-33

PMID:10388805 - Regulation of mRNA export by nutritional status in fission yeast.

Whalen WA et al. Genetics 1999 Jul;152(3):827-38

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12110682 - Elf1p, a member of the ABC class of ATPases, functions as a mRNA export factor in Schizosacchromyces pombe.

Kozak L et al. J Biol Chem 2002 Sep 13;277(37):33580-9

PMID:28799069 - Rae1-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling.

Satoh R et al. Curr Genet 2018 Feb;64(1):103-108

PMID:12112233 - Schizosaccharomyces pombe spPABP, a homologue of Saccharomyces cerevisiae Pab1p, is a non-essential, shuttling protein that facilitates mRNA export.

Thakurta AG et al. Yeast 2002 Jun 30;19(9):803-10

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.

Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:31015410 - Nuclear membrane protein Lem2 regulates nuclear size through membrane flow.

Kume K et al. Nat Commun 2019 Apr 23;10(1):1871

PMID:33946513 - The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.

Yukawa M et al. Int J Mol Sci 2021 Apr 30;22(9)

PMID:28545058 - A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

Kume K et al. PLoS Genet 2017 May;13(5):e1006767