protein coding gene - eso1 (SPBC16A3.11) - mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein

Gene summary

Standard name

eso1

Systematic ID

SPBC16A3.11

Product

mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O42917

ORFeome ID

38/38F08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 4276864..4279653 reverse strand

Annotation

Protein features

Orthologs

• ESCO1 (HGNC:24645) Homo sapiens
• POLH (HGNC:9181) Homo sapiens
• eso1 (SJAG_04791) Schizosaccharomyces japonicus
• RAD30 (YDR419W) Saccharomyces cerevisiae
• ECO1 (YFR027W) Saccharomyces cerevisiae

References / Literature

PMID:26147350 - The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage.

Uchiyama M et al. PLoS One 2015;10(7):e0130000

PMID:29352077 - Whole-Genome Sequencing of Suppressor DNA Mixtures Identifies Pathways That Compensate for Chromosome Segregation Defects in Schizosaccharomyces pombe .

Xu X et al. G3 (Bethesda) 2018 Mar 02;8(3):1031-1038

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23628481 - A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Yu Y et al. DNA Repair (Amst) 2013 Jun 01;12(6):433-43

PMID:21300781 - Psm3 acetylation on conserved lysine residues is dispensable for viability in fission yeast but contributes to Eso1-mediated sister chromatid cohesion by antagonizing Wpl1.

Feytout A et al. Mol Cell Biol 2011 Apr;31(8):1771-86

PMID:24375893 - Identification of two forms of the Eso1 protein in Schizosaccharomyces pombe.

Chen Z et al. Cell Biol Int 2014 May;38(5):682-8

PMID:12514100 - Checkpoint activation regulates mutagenic translesion synthesis.

Kai M et al. Genes Dev 2003 Jan 01;17(1):64-76

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:27473316 - Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Ranatunga NS et al. G3 (Bethesda) 2016 Oct 13;6(10):3049-3063

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:28382430 - DNA Topoisomerase II modulates acetyl-regulation of cohesin-mediated chromosome dynamics.

Lin SJ et al. Curr Genet 2017 Oct;63(5):923-930

PMID:31895039 - The CDK Pef1 and protein phosphatase 4 oppose each other for regulating cohesin binding to fission yeast chromosomes.

Birot A et al. Elife 2020 Jan 02;9

PMID:11359920 - Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.

Takeda T et al. Mol Biol Cell 2001 May;12(5):1257-74

PMID:15972456 - Brc1-mediated DNA repair and damage tolerance.

Sheedy DM et al. Genetics 2005 Oct;171(2):457-68

PMID:20176980 - Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

Dolan WP et al. Genetics 2010 May;185(1):39-53

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PB_REF:0000003 - Disease Association Curation

PMID:20404181 - Postreplication gaps at UV lesions are signals for checkpoint activation.

Callegari AJ et al. Proc Natl Acad Sci U S A 2010 May 04;107(18):8219-24

PMID:25293972 - Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL et al. Genetics 2014 Dec;198(4):1457-72

PMID:18079700 - Cell-cycle regulation of cohesin stability along fission yeast chromosomes.

Bernard P et al. EMBO J 2008 Jan 09;27(1):111-21

PMID:11598020 - Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.

Tanaka K et al. EMBO J 2001 Oct 15;20(20):5779-90

PMID:21979813 - Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.

Kagami A et al. EMBO Rep 2011 Oct 28;12(11):1189-95

PMID:20453833 - Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast.

Coulon S et al. EMBO J 2010 Jun 16;29(12):2048-58

PMID:16682348 - A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4.

Bernard P et al. Curr Biol 2006 May 09;16(9):875-81

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:17515930 - Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice.

Kai M et al. Nat Cell Biol 2007 Jun;9(6):691-7

PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8

PMID:26652183 - Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.

Callegari AJ et al. Cell Cycle 2016;15(2):261-73

PMID:22308326 - Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility.

Zamir L et al. Proc Natl Acad Sci U S A 2012 Feb 14;109(7):E406-14

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:27687866 - Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Noguchi C et al. Cell Cycle 2017 Jan 02;16(1):45-58

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28343969 - Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.

Goto Y et al. Curr Biol 2017 Apr 03;27(7):1005-1012

PMID:28438891 - A second Wpl1 anti-cohesion pathway requires dephosphorylation of fission yeast kleisin Rad21 by PP4.

Birot A et al. EMBO J 2017 May 15;36(10):1364-1378

PMID:29039458 - DNA polymerase 5 acetylation by Eso1 is essential for Schizosaccharomyces pombe viability.

Chen Z et al. Int J Mol Med 2017 Dec;40(6):1907-1913

PMID:31278118 - Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD et al. Genetics 2019 Sep;213(1):127-141

PMID:17277362 - Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.

Lee KM et al. Genetics 2007 Apr;175(4):1585-95

PMID:32034465 - Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.

Anandarajan V et al. Curr Genet 2020 Jun;66(3):593-605

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:34228709 - Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.

Soriano I et al. PLoS Genet 2021 Jul;17(7):e1009526

PMID:18414064 - Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.

Kato H et al. Cell Cycle 2008 Apr 15;7(8):1085-96

PMID:10779336 - Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.

Tanaka K et al. Mol Cell Biol 2000 May;20(10):3459-69

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:19416828 - Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.

Inagawa T et al. Proc Natl Acad Sci U S A 2009 May 12;106(19):7927-32

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27798241 - An acetyltransferase-independent function of Eso1 regulates centromere cohesion.

Lin SJ et al. Mol Biol Cell 2016 Dec 15;27(25):4002-4010

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

GO_REF:0000002 - Comments

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:38830897 - Sororin is an evolutionary conserved antagonist of WAPL.

Prusén Mota I et al. Nat Commun 2024 Jun 03;15(1):4729

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83