protein coding gene - SPBC16A3.12c - triglyceride lipase-ergosterol esterase

Gene summary

Systematic ID: SPBC16A3.12c
Product: triglyceride lipase-ergosterol esterase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: P78898
ORFeome ID: 26/26A11
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 4275235..4277062 forward strand

Annotation

Disease association

MONDO:0019149 - cholesteryl ester storage disease

References:

PB_REF:0000006

MONDO:0002561 - lysosomal storage disease

References:

PB_REF:0000003

MONDO:0005066 - metabolic disease

References:

PB_REF:0000003

MONDO:0019148 - Wolman disease

References:

PB_REF:0000006

GO biological process

GO:0008204 - ergosterol metabolic process

References:

GO_REF:0000024

GO cellular component

GO:0005737 - cytoplasm

References:

PMID:16823372

GO:0000324 - fungal-type vacuole

References:

PMID:16823372

GO:0005773 - vacuole

References:

PMID:16823372

GO molecular function

GO:0004771 - sterol ester esterase activity

References:

GO_REF:0000033

Modification

MOD:00006 - N-glycosylated residue

References:

PMID:36408920

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002693 - resistance to diamide

References:

PMID:37787768

Genotypes:

SPBC16A3.12cdelta

FYPO:0001453 - resistance to ethanol

References:

PMID:37787768

Genotypes:

SPBC16A3.12cdelta

FYPO:0001583 - resistance to lithium

References:

PMID:37787768

Genotypes:

SPBC16A3.12cdelta

FYPO:0000725 - resistance to methyl methanesulfonate

References:

PMID:37787768

Genotypes:

SPBC16A3.12cdelta

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

PMID:37787768

Genotypes:

SPBC16A3.12cdelta

FYPO:0003383 - resistance to tert-butyl hydroperoxide

References:

PMID:37787768

Genotypes:

SPBC16A3.12cdelta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

SPBC16A3.12cdelta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

SPBC16A3.12cdelta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

ID	Name	InterPro name	DB name
PF04083	Abhydro_lipase	AB_hydrolase_lipase	PFAM
G3DSA:3.40.50.1820:FF:000095			FUNFAM
SSF53474	alpha/beta-Hydrolases	AB_hydrolase_fold	SUPERFAMILY
G3DSA:3.40.50.1820	alpha/beta hydrolase	AB_hydrolase_fold	GENE3D
PTHR11005	LYSOSOMAL ACID LIPASE-RELATED		PANTHER
PIRSF000862	Steryl_ester_lip	Lipase_euk	PIRSF

Orthologs

LIPJ (HGNC:21773) Homo sapiens
LIPK (HGNC:23444) Homo sapiens
LIPM (HGNC:23455) Homo sapiens
LIPA (HGNC:6617) Homo sapiens
LIPF (HGNC:6622) Homo sapiens
SJAG_04790 Schizosaccharomyces japonicus
TGL1 (YKL140W) Saccharomyces cerevisiae

References / Literature

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.: Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PB_REF:0000003 - Disease Association Curation
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.: Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704