protein coding gene - sec27 (SPBC16C6.13c) - coatomer beta' subunit

Gene summary

Standard name: sec27
Systematic ID: SPBC16C6.13c
Product: coatomer beta' subunit
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPBC244.03
UniProt ID: O42937
ORFeome ID: 28/28G08
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 4354162..4357141 reverse strand

Annotation

Disease association

MONDO:0054716 - microcephaly 19, primary, autosomal recessive

References:

PB_REF:0000006

MONDO:0859253 - osteoporosis, childhood- or juvenile-onset, with developmental delay

References:

PB_REF:0000006

GO biological process

GO:0006886 - intracellular protein transport

References:

GO_REF:0000002

GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

References:

GO_REF:0000024

GO cellular component

GO:0030126 - COPI vesicle coat

References:

GO_REF:0000024

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0005198 - structural molecule activity

References:

GO_REF:0000002

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein features

PBO:0111751 - WD repeat protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

sec27delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

sec27delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

sec27delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00400	WD40	WD40_rpt	Pfam
PF04053	B-prop_COPA_B_2nd	Beta-prop_COPA/B_2nd	Pfam
PF23953	TPR_COPA_B	TPR_COPA_B	Pfam
cd00200	WD40		CDD
cd22947	Coatomer_WDAD_beta-like		CDD
PS50082	WD_REPEATS_2	WD40_rpt	PROSITE profiles
PS50294	WD_REPEATS_REGION		PROSITE profiles
SM00320	WD40	WD40_rpt	SMART
PR00320	GPROTEINBRPT	WD40_PAC1	PRINTS
G3DSA:1.25.40.470:FF:000001			CATH-FunFam
G3DSA:2.130.10.10:FF:000016			CATH-FunFam
G3DSA:1.25.40.470			CATH-Gene3D
G3DSA:2.130.10.10		WD40/YVTN_repeat-like_dom_sf	CATH-Gene3D
SSF50978		WD40_repeat_dom_sf	SUPERFAMILY
PTHR19876		Coatomer_complex_subunit	PANTHER
PIRSF005567	Coatomer_beta'_subunit	COPB2	PIRSF

Orthologs

COPB2 (HGNC:2232) Homo sapiens
sec27 (SJAG_04070) Schizosaccharomyces japonicus
SEC27 (YGL137W) Saccharomyces cerevisiae

References / Literature

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.: Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.: Mak T et al. EMBO J 2021 Aug 16;40(16):e107911