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protein coding gene - spo2 (SPBC16C6.14) - sporulation specific protein Spo2

Gene summary

Standard name
spo2
Systematic ID
SPBC16C6.14
Product
sporulation specific protein Spo2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
C6Y4C2
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4322024..4322622 reverse strand

Annotation

GO biological process

GO:0030437 - ascospore formation

References:

GO:0031322 - ascospore-type prospore-specific spindle pole body remodeling

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GO cellular component

GO:0035974 - meiotic spindle pole body

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GO molecular function

GO:0005515 - protein binding

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Qualitative gene expression

PomGeneEx:0000015 - RNA absent

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0000585 - abolished ascospore wall biogenesis

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0003541 - normal protein localization to meiotic spindle pole body

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:20833892 - Schizosaccharomyces pombe calmodulin, Cam1, plays a crucial role in sporulation by recruiting and stabilizing the spindle pole body components responsible for assembly of the forespore membrane.
Itadani A et al. Eukaryot Cell 2010 Dec;9(12):1925-35
PMID:18367542 - Meiotic spindle pole bodies acquire the ability to assemble the spore plasma membrane by sequential recruitment of sporulation-specific components in fission yeast.
Nakase Y et al. Mol Biol Cell 2008 Jun;19(6):2476-87
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:3442824 - Genetic mapping of eleven spo genes essential for ascospore formation in the fission yeast Schizosaccharomyces pombe.
Kishida M et al. Curr Genet 1986;10(6):443-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:1417417 - Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe.
Hirata A et al. Arch Microbiol 1992;158(4):249-55
PMID:21775631 - The fission yeast pleckstrin homology domain protein Spo7 is essential for initiation of forespore membrane assembly and spore morphogenesis.
Nakamura-Kubo M et al. Mol Biol Cell 2011 Sep;22(18):3442-55