protein coding gene - zrt1 (SPBC16D10.06) - plasma membrane ZIP zinc transmembrane transporter Zrt1

Gene summary

Standard name

zrt1

Systematic ID

SPBC16D10.06

Product

plasma membrane ZIP zinc transmembrane transporter Zrt1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O94639

ORFeome ID

19/19E07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3607177..3609330 forward strand

Annotation

Protein features

Orthologs

• SLC39A1 (HGNC:12876) Homo sapiens
• SLC39A2 (HGNC:17127) Homo sapiens
• SLC39A3 (HGNC:17128) Homo sapiens
• zrt1 (SJAG_04185) Schizosaccharomyces japonicus
• ZRT1 (YGL255W) Saccharomyces cerevisiae
• ZRT2 (YLR130C) Saccharomyces cerevisiae

References / Literature

PMID:28160081 - Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological life span in fission yeast.

Shimasaki T et al. Mol Genet Genomics 2017 Apr;292(2):475-481

PMID:18203864 - Response of Schizosaccharomyces pombe to zinc deficiency.

Dainty SJ et al. Eukaryot Cell 2008 Mar;7(3):454-64

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:24003116 - Zinc finger protein Loz1 is required for zinc-responsive regulation of gene expression in fission yeast.

Corkins ME et al. Proc Natl Acad Sci U S A 2013 Sep 17;110(38):15371-6

PMID:18637840 - Loss of Zhf and the tightly regulated zinc-uptake system SpZrt1 in Schizosaccharomyces pombe reveals the delicacy of cellular zinc balance.

Boch A et al. FEMS Yeast Res 2008 Sep;8(6):883-96

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:31515876 - The Loz1 transcription factor from Schizosaccharomyces pombe binds to Loz1 response elements and represses gene expression when zinc is in excess.

Wilson S et al. Mol Microbiol 2019 Dec;112(6):1701-1717

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.

Bednor L et al. mBio 2023 Dec 22;:e0306223

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:25204792 - Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.

Ohtsuka H et al. Mol Genet Genomics 2015 Feb;290(1):173-85

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.

Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72

PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.

Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70

PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.

Calvo IA et al. iScience 2021 Nov 19;24(11):103338

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:29529046 - Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol.

Choi S et al. PLoS Genet 2018 Mar;14(3):e1007262

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:24831008 - The double zinc finger domain and adjacent accessory domain from the transcription factor loss of zinc sensing 1 (loz1) are necessary for DNA binding and zinc sensing.

Ehrensberger KM et al. J Biol Chem 2014 Jun 27;289(26):18087-96

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053