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protein coding gene - tad2 (SPBC16D10.10) - tRNA specific adenosine-34 deaminase subunit Tad2

Gene summary

Standard name
tad2
Systematic ID
SPBC16D10.10
Product
tRNA specific adenosine-34 deaminase subunit Tad2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94642
ORFeome ID
23/23B06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3617976..3619540 forward strand

Annotation

GO biological process

GO:0002100 - tRNA wobble adenosine to inosine editing

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005634 - nucleus

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GO:0052718 - tRNA-specific adenosine-34 deaminase complex

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GO molecular function

GO:0005524 - ATP binding

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GO:0052717 - tRNA-specific adenosine-34 deaminase activity

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GO:0008270 - zinc ion binding

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GO:0016301 - kinase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000951 - inviable small vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Subunit composition

PBO:0015221 - heteromeric(2)

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PBO:0091843 - II:g.3619003_3619004insG

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PBO:0000129 - sequence error in genomic data

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Protein features

IDNameInterPro nameDB name
PF00383dCMP_cyt_deam_1CMP_dCMP_domPfam
PF00485PRKPRK/URKPfam
cd01285nucleoside_deaminaseCDD
PS00903CYT_DCMP_DEAMINASES_1APOBEC/CMP_deaminase_Zn-bdPROSITE patterns
PS51747CYT_DCMP_DEAMINASES_2CMP_dCMP_domPROSITE profiles
PR00988URIDINKINASEPRINTS
G3DSA:3.40.140.10:FF:000039CATH-FunFam
G3DSA:3.40.140.10CATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
SSF53927Cytidine_deaminase-likeSUPERFAMILY
PTHR11079PANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
PMID:34194665 - Functional and structural investigation of N-terminal domain of the SpTad2/3 heterodimeric tRNA deaminase.
Liu X et al. Comput Struct Biotechnol J 2021;19:3384-3393
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:17875641 - Wobble inosine tRNA modification is essential to cell cycle progression in G(1)/S and G(2)/M transitions in fission yeast.
Tsutsumi S et al. J Biol Chem 2007 Nov 16;282(46):33459-33465
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963