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protein coding gene - rem1 (SPBC16E9.17c) - meiosis specific cyclin Rem1

Gene summary

Standard name
rem1
Systematic ID
SPBC16E9.17c
Product
meiosis specific cyclin Rem1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O14332
ORFeome ID
32/32G07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1953419..1954712 reverse strand

Annotation

Comment

PBO:0091288 - meiosis specific splicing

References:

GO biological process

GO:0033260 - nuclear DNA replication

References:

GO:0007131 - reciprocal meiotic recombination

References:

GO:0051445 - regulation of meiotic cell cycle

References:

GO:0023052 - signaling

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GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

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GO:0005829 - cytosol

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GO:0005815 - microtubule organizing center

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GO:0005635 - nuclear envelope

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GO:0005634 - nucleus

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GO molecular function

GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity

References:

Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0004608 - abnormal spindle pole body morphology during meiosis II

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

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Genotypes:

FYPO:0004760 - abnormal sporulation resulting in formation of azygotic ascus with more than four spores

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Genotypes:

FYPO:0004800 - abolished premeiotic DNA replication during azygotic meiotic cell cycle

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

Protein features

PBO:0111870 - B-type cyclin

PBO:0111794 - cyclin

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00134Cyclin_NCyclin_NPfam
PF02984Cyclin_CCyclin_C-domPfam
cd20536CYCLIN_CCNO_rpt1CDD
PS00292CYCLINSCyclins_cyclin-boxPROSITE patterns
SM00385CYCLINCyclin-like_domSMART
SM01332Cyclin_CCyclin_C-domSMART
G3DSA:1.10.472.10:FF:000001CATH-FunFam
G3DSA:1.10.472.10CATH-Gene3D
SSF47954Cyclin-like_sfSUPERFAMILY
PTHR10177CyclinPANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16024772 - A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis.
Malapeira J et al. Mol Cell Biol 2005 Aug;25(15):6330-7
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
Gutiérrez-Escribano P et al. Nat Commun 2015 Apr 20;6:6871
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000051 - S. pombe keyword mapping
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704