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protein coding gene - rrp42 (SPBC16G5.10) - exosome subunit Rrp42

Gene summary

Standard name
rrp42
Systematic ID
SPBC16G5.10
Product
exosome subunit Rrp42
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60124
ORFeome ID
14/14F01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4231941..4234086 forward strand

Annotation

GO biological process

GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

References:

GO:0070651 - nonfunctional rRNA decay

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GO:0071028 - nuclear mRNA surveillance

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GO:0071042 - nuclear polyadenylation-dependent mRNA catabolic process

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GO:0071035 - nuclear polyadenylation-dependent rRNA catabolic process

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GO:0070478 - nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

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GO:0070481 - nuclear-transcribed mRNA catabolic process, non-stop decay

References:

GO:0071038 - TRAMP-dependent tRNA surveillance pathway

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GO:0034473 - U1 snRNA 3'-end processing

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GO:0034475 - U4 snRNA 3'-end processing

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GO:0034476 - U5 snRNA 3'-end processing

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GO cellular component

GO:0000177 - cytoplasmic exosome (RNase complex)

References:

GO:0005829 - cytosol

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GO:0000178 - exosome (RNase complex)

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GO:0000176 - nuclear exosome (RNase complex)

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GO:0005634 - nucleus

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GO molecular function

GO:0000175 - 3'-5'-RNA exonuclease activity

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GO:0035925 - mRNA 3'-UTR AU-rich region binding

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002421 - inviable after spore germination, single or double cell division, abnormal cell shape

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01138RNase_PHExoRNase_PH_dom1PFAM
G3DSA:3.30.230.70:FF:000061FUNFAM
SSF55666Ribonuclease PH domain 2-likeExoRNase_PH_dom2_sfSUPERFAMILY
SSF54211Ribosomal protein S5 domain 2-likeRibosomal_Su5_D2-typ_SFSUPERFAMILY
G3DSA:3.30.230.70PNPase/RNase_PH_dom_sfGENE3D
PTHR11097EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEINExosome_comp_Rrp42_subfamPANTHER

Orthologs

References / Literature

PMID:23755256 - The Sm complex is required for the processing of non-coding RNAs by the exosome.
Coy S et al. PLoS One 2013;8(6):e65606
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:29906447 - Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
Weick EM et al. Cell 2018 Jun 14;173(7):1663-1677.e21
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.
Lee NN et al. Cell 2013 Nov 21;155(5):1061-74
PMID:23503588 - The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.
Malecki M et al. EMBO J 2013 Jul 03;32(13):1842-54
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183