protein coding gene - rip1 (SPBC16H5.06) - ubiquinol-cytochrome-c reductase complex subunit 5, Rieske iron-sulfur protein, Rip1

Gene summary

Standard name

rip1

Systematic ID

SPBC16H5.06

Product

ubiquinol-cytochrome-c reductase complex subunit 5, Rieske iron-sulfur protein, Rip1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q09154

ORFeome ID

31/31G11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2288882..2290113 reverse strand

Annotation

Protein features

Orthologs

• UQCRFS1 (HGNC:12587) Homo sapiens
• rip1 (SJAG_00601) Schizosaccharomyces japonicus
• RIP1 (YEL024W) Saccharomyces cerevisiae

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.

Sun LL et al. PLoS Genet 2013;9(8):e1003715

PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.

Sieber B et al. Nat Commun 2026 Mar 17;

GO_REF:0000002 - Comments

PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23832353 - The fission yeast php2 mutant displays a lengthened chronological lifespan.

Takuma K et al. Biosci Biotechnol Biochem 2013;77(7):1548-55

PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.

Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:38360270 - A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in fission yeast.

Zhu M et al. J Biol Chem 2024 Feb 13;:105754

PB_REF:0000003 - Disease Association Curation

PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.

Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678

PMID:9535840 - Processing of the presequence of the Schizosaccharomyces pombe Rieske iron-sulfur protein occurs in a single step and can be converted to two-step processing by mutation of a single proline to serine in the presequence.

Nett JH et al. J Biol Chem 1998 Apr 10;273(15):8652-8

PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.

Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738

GO_REF:0000051 - S. pombe keyword mapping

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

GO_REF:0000108 - Automatic assignment of GO terms using logical inference, based on on inter-ontology links.

PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.

Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:37164017 - Optimization of energy production and central carbon metabolism in a non-respiring eukaryote.

Alam S et al. Curr Biol 2023 Jun 05;33(11):2175-2186.e5

PMID:8663290 - Heterologous complementation of a Rieske iron-sulfur protein-deficient Saccharomyces cerevisiae by the Rip1 gene of Schizosaccharomyces pombe.

di Rago JP et al. J Biol Chem 1996 Jun 28;271(26):15341-5

PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.

Su Y et al. FEBS J 2017 Jan;284(2):324-337

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:37859837 - In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions.

Mori A et al. R Soc Open Sci 2023 Oct;10(10):230404

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531