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protein coding gene - rip1 (SPBC16H5.06) - ubiquinol-cytochrome-c reductase complex subunit 5, Rieske iron-sulfur protein, Rip1

Gene summary

Standard name
rip1
Systematic ID
SPBC16H5.06
Product
ubiquinol-cytochrome-c reductase complex subunit 5, Rieske iron-sulfur protein, Rip1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q09154
ORFeome ID
31/31G11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2288882..2290113 reverse strand

Annotation

PBO:0002678 - 1.10.2.2

Complementation

PBO:0008948 - functionally complements S. cerevisiae RIP1

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Disease association

MONDO:0015448 - mitochondrial complex III deficiency

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MONDO:0032909 - mitochondrial complex III deficiency, nuclear type 10

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GO biological process

GO:0006122 - mitochondrial electron transport, ubiquinol to cytochrome c

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GO cellular component

GO:0005743 - mitochondrial inner membrane

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GO:0005739 - mitochondrion

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GO:0045275 - respiratory chain complex III

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GO molecular function

GO:0051537 - 2 iron, 2 sulfur cluster binding

References:

GO:0008121 - quinol-cytochrome-c reductase activity

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Modification

MOD:00689 - disulfide crosslinked residues

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MOD:00046 - O-phospho-L-serine

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Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000357 - abnormal shmoo morphology

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Genotypes:

FYPO:0006141 - abolished cell population growth on gluconate carbon source

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Genotypes:

FYPO:0001934 - abolished cell population growth on glycerol carbon source

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Genotypes:

FYPO:0006010 - abolished shmoo contact with partner cell

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0008128 - decreased vegetative cell population growth on low glucose

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Genotypes:

FYPO:0007618 - delayed onset of protein export from nucleus

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Genotypes:

FYPO:0006012 - elongated cell with abolished shmoo formation

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0007612 - increased transcription from STREP promoter

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Genotypes:

FYPO:0006013 - large ascus

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Genotypes:

FYPO:0002620 - normal growth on trichostatin A

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Genotypes:

FYPO:0009066 - resistance to amorolfine

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002617 - sensitive to sodium butyrate

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Genotypes:

FYPO:0000086 - sensitive to tacrolimus

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0000022 - shmoo with long tip

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02921UCR_TMRieske_TMPFAM
PF00355RieskeRieske_2Fe-2SPFAM
cd03470Rieske_cytochrome_bc1CDD
PS51296RIESKERieske_2Fe-2SPROSITE_PROFILES
PR00162RIESKERieske_Fe-S_prot_CPRINTS
G3DSA:2.102.10.10:FF:000001FUNFAM
SSF50022ISP domainRieske_2Fe-2S_sfSUPERFAMILY
SSF81502ISP transmembrane anchorSUPERFAMILY
G3DSA:1.20.5.270Ubiquinol cytochrome reductase, transmembrane domainbc1_Rieske_TM_sfGENE3D
G3DSA:2.102.10.10Rieske_2Fe-2S_sfGENE3D
PTHR10134CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIALRieske_Fe-S_protPANTHER
TIGR01416Rieske_proteoUbiquinol_cyt_c_Rdtase_Fe-S-suNCBIFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23231582 - Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe.
Carter-O'Connell I et al. BMC Genomics 2012 Dec 12;13:697
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.
Zhang L et al. PLoS One 2013;8(7):e68738
PMID:9535840 - Processing of the presequence of the Schizosaccharomyces pombe Rieske iron-sulfur protein occurs in a single step and can be converted to two-step processing by mutation of a single proline to serine in the presequence.
Nett JH et al. J Biol Chem 1998 Apr 10;273(15):8652-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.
Sieber B et al. Nat Commun 2026 Mar 17;
PMID:27886462 - Loss of ppr3, ppr4, ppr6, or ppr10 perturbs iron homeostasis and leads to apoptotic cell death in Schizosaccharomyces pombe.
Su Y et al. FEBS J 2017 Jan;284(2):324-337
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000002 - Comments
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:18665268 - Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.
Zuin A et al. PLoS One 2008 Jul 30;3(7):e2842
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:37859837 - In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions.
Mori A et al. R Soc Open Sci 2023 Oct;10(10):230404
PMID:38360270 - A KDELR-mediated ER-retrieval system modulates mitochondrial functions via the unfolded protein response in fission yeast.
Zhu M et al. J Biol Chem 2024 Feb 13;:105754
GO_REF:0000051 - S. pombe keyword mapping
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:37939086 - Structure and function of the S. pombe III-IV-cyt c supercomplex.
Moe A et al. Proc Natl Acad Sci U S A 2023 Nov 14;120(46):e2307697120
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:37164017 - Optimization of energy production and central carbon metabolism in a non-respiring eukaryote.
Alam S et al. Curr Biol 2023 Jun 05;33(11):2175-2186.e5
PB_REF:0000003 - Disease Association Curation
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:8663290 - Heterologous complementation of a Rieske iron-sulfur protein-deficient Saccharomyces cerevisiae by the Rip1 gene of Schizosaccharomyces pombe.
di Rago JP et al. J Biol Chem 1996 Jun 28;271(26):15341-5
PMID:23832353 - The fission yeast php2 mutant displays a lengthened chronological lifespan.
Takuma K et al. Biosci Biotechnol Biochem 2013;77(7):1548-55
PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.
Ma Y et al. PLoS One 2011;6(8):e23422
PMID:33400299 - Role of mitochondrial complex III/IV in the activation of transcription factor Rst2 in Schizosaccharomyces pombe.
Jiang G et al. Mol Microbiol 2021 Jun;115(6):1323-1338
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:39289458 - Characterization of Shy1, the Schizosaccharomyces pombe homolog of human SURF1.
Luo Y et al. Sci Rep 2024 Sep 17;14(1):21678
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7