protein coding gene - ppa2 (SPBC16H5.07c) - serine/threonine protein phosphatase PP2A catalytic subunit Ppa2

Gene summary

Standard name

ppa2

Systematic ID

SPBC16H5.07c

Product

serine/threonine protein phosphatase PP2A catalytic subunit Ppa2

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P23636

ORFeome ID

32/32G03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2286952..2290445 forward strand

Annotation

Protein features

Orthologs

• PPP2CA (HGNC:9299) Homo sapiens
• PPP2CB (HGNC:9300) Homo sapiens
• SJAG_00600 Schizosaccharomyces japonicus
• PPH21 (YDL134C) Saccharomyces cerevisiae
• PPH22 (YDL188C) Saccharomyces cerevisiae

References / Literature

PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .

Wiley DJ et al. Front Physiol 2020;11:427

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:2170029 - Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.

Kinoshita N et al. Cell 1990 Oct 19;63(2):405-15

PMID:1756736 - The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Warbrick E et al. EMBO J 1991 Dec;10(13):4291-9

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:22375062 - Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.

Buttrick GJ et al. J Cell Sci 2012 Apr 01;125(Pt 7):1645-51

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:40873007 - PPA2 activates MTFP1-DNM1L fission signaling to govern mitochondrial proliferation and mitophagy.

Mishra SR et al. Autophagy 2026 Jan;22(1):121-144

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:1944266 - The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control.

Kinoshita N et al. Mol Cell Biol 1991 Dec;11(12):5839-47

PMID:19371376 - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Hanyu Y et al. Genes Cells 2009 May;14(5):539-54

PMID:8389306 - Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

Kinoshita N et al. Genes Dev 1993 Jun;7(6):1059-71

PMID:16541024 - Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Riedel CG et al. Nature 2006 May 04;441(7089):53-61

PMID:7983142 - A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning.

Yoshida T et al. J Cell Sci 1994 Jul;107 ( Pt 7):1725-35

PMID:24634168 - Proteome-wide search for PP2A substrates in fission yeast.

Bernal M et al. Proteomics 2014 Jun;14(11):1367-80

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:27398807 - Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Nie M et al. PLoS Genet 2016 Jul;12(7):e1006165

PMID:33888556 - Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.

Ma W et al. Genes Dev 2021 May 01;35(9-10):692-697

PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.

Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A et al. Genetics 2012 Apr;190(4):1235-50

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:20383139 - Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.

Ishiguro T et al. Nat Cell Biol 2010 May;12(5):500-6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30

PMID:31833215 - Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.

Shetty M et al. Aging Cell 2020 Feb;19(2):e13068

PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.

Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130

PMID:22403715 - Regulation of fission yeast morphogenesis by PP2A activator pta2.

Bernal M et al. PLoS One 2012;7(3):e32823

PMID:11380623 - Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin.

Tanabe O et al. Genes Cells 2001 May;6(5):455-73

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:8387356 - Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

Shimanuki M et al. Mol Biol Cell 1993 Mar;4(3):303-13

PMID:10684278 - Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr.

Masuda M et al. J Virol 2000 Mar;74(6):2636-46

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:26152587 - TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1.

Laor D et al. mBio 2015 Jul 07;6(4):e00959

PMID:16297994 - Fission yeast homologue of Tip41-like proteins regulates type 2A phosphatases and responses to nitrogen sources.

Fenyvuesvolgyi C et al. Biochim Biophys Acta 2005 Dec 15;1746(2):155-62

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:22624651 - A systematic screen reveals new elements acting at the G2/M cell cycle control.

Navarro FJ et al. Genome Biol 2012 May 24;13(5):R36

PMID:9078365 - The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis.

Kinoshita K et al. Genes Cells 1996 Jan;1(1):29-45

PMID:38971312 - TORC2 is required for accumulation of γH2A in response to DNA damage.

Cohen A et al. J Biol Chem 2024 Jul 04;:107531

PMID:25483073 - Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mojardín L et al. Cell Cycle 2015;14(2):206-18

PMID:30154212 - Nutritional cell cycle reprogramming reveals that inhibition of Cdk1 is required for proper MBF-dependent transcription.

Rubio A et al. J Cell Sci 2018 Sep 20;131(18)

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.

Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.

Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14

PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:36006032 - Analysis of the potential role of fission yeast PP2A in spindle assembly checkpoint inactivation.

Deng DJ et al. FASEB J 2022 Sep;36(9):e22524