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protein coding gene - omh2 (SPBC16H5.09c) - alpha-1,2-mannosyltransferase Omh2

Gene summary

Standard name
omh2
Systematic ID
SPBC16H5.09c
Product
alpha-1,2-mannosyltransferase Omh2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O42944
ORFeome ID
20/20B07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2282418..2283951 forward strand

Annotation

PBO:0000169 - 2.4.1.-

GO biological process

GO:0000032 - cell wall mannoprotein biosynthetic process

References:

GO:0006487 - protein N-linked glycosylation

References:

GO:0006493 - protein O-linked glycosylation

References:

GO cellular component

GO:0000139 - Golgi membrane

References:

GO molecular function

GO:0000026 - alpha-1,2-mannosyltransferase activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002626 - resistance to heat

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Protein features

IDNameInterPro nameDB name
PF01793Glyco_transf_15Glyco_trans_15PFAM
G3DSA:3.90.550.10:FF:000051FUNFAM
SSF53448Nucleotide-diphospho-sugar transferasesNucleotide-diphossugar_transSUPERFAMILY
G3DSA:3.90.550.10Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain ANucleotide-diphossugar_transGENE3D
PTHR31121ALPHA-1,2 MANNOSYLTRANSFERASE KTR1Glyco_trans_15PANTHER
PIRSF018153Glycolip_mannosyltransf_fungGlyco_trans_15PIRSF

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:19054127 - Identification and characterization of a gene required for alpha1,2-mannose extension in the O-linked glycan synthesis pathway in Schizosaccharomyces pombe.
Ikeda Y et al. FEMS Yeast Res 2009 Feb;9(1):115-25
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8