protein coding gene - skb1 (SPBC16H5.11c) - type II protein arginine N-methyltransferase Skb1

Gene summary

Standard name

skb1

Systematic ID

SPBC16H5.11c

Product

type II protein arginine N-methyltransferase Skb1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

rmt5

UniProt ID

P78963

ORFeome ID

33/33F07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2277255..2279624 forward strand

Annotation

Protein features

Orthologs

• PRMT5 (HGNC:10894) Homo sapiens
• skb1 (SJAG_00596) Schizosaccharomyces japonicus
• HSL7 (YBR133C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:11278267 - The highly conserved protein methyltransferase, Skb1, is a mediator of hyperosmotic stress response in the fission yeast Schizosaccharomyces pombe.

Bao S et al. J Biol Chem 2001 May 04;276(18):14549-52

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:10593886 - Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.

Yang P et al. J Biol Chem 1999 Dec 17;274(51):36052-7

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25009287 - Megadalton-node assembly by binding of Skb1 to the membrane anchor Slf1.

Deng L et al. Mol Biol Cell 2014 Sep 01;25(17):2660-8

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:8943016 - The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog.

Gilbreth M et al. Proc Natl Acad Sci U S A 1996 Nov 26;93(24):13802-7

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:17213188 - Regulation of the nuclear poly(A)-binding protein by arginine methylation in fission yeast.

Perreault A et al. J Biol Chem 2007 Mar 09;282(10):7552-62

PMID:18505873 - Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.

Gómez EB et al. Genetics 2008 Jun;179(2):757-71

PMID:9843966 - Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs.

Gilbreth M et al. Proc Natl Acad Sci U S A 1998 Dec 08;95(25):14781-6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:37237082 - Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere.

Mongia P et al. Commun Biol 2023 May 26;6(1):551

PMID:10637604 - Cell-cycle regulatory proteins Hsl7p/Skb1p belong to the protein methyltransferase superfamily.

Ma XJ Trends Biochem Sci 2000 Jan;25(1):11-2

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:9660817 - Cloning and characterization of shk2, a gene encoding a novel p21-activated protein kinase from fission yeast.

Yang P et al. J Biol Chem 1998 Jul 17;273(29):18481-9

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:12646585 - Control of cell polarity in fission yeast by association of Orb6p kinase with the highly conserved protein methyltransferase Skb1p.

Wiley DJ et al. J Biol Chem 2003 Jul 04;278(27):25256-63

PMID:11751918 - The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Taricani L et al. J Biol Chem 2002 Mar 22;277(12):10562-72

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71