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protein coding gene - SPBC16H5.14c - short chain dehydrogenase DHRS3 family, implicated in lipid (isoprenoid) metabolism

Gene summary

Systematic ID
SPBC16H5.14c
Product
short chain dehydrogenase DHRS3 family, implicated in lipid (isoprenoid) metabolism
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC21H7.08
UniProt ID
Q1MTR7
ORFeome ID
13/13G04
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome II: 2268404..2270305 forward strand

Annotation

Disease association

MONDO:0980974 - craniosynostosis-scoliosis syndrome

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:0005739 - mitochondrion

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GO molecular function

GO:0016491 - oxidoreductase activity

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009007 - decreased vegetative cell population viability

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009071 - sensitive to itraconazole

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00106adh_shortSDR_famPfam
cd0533917beta-HSDXI-like_SDR_cCDD
PR00081GDHRDHSDR_famPRINTS
G3DSA:3.40.50.720CATH-Gene3D
SSF51735NAD(P)-bd_dom_sfSUPERFAMILY
PTHR24322PANTHER

Orthologs

References / Literature

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.
Rodriguez-Lopez M et al. Elife 2022 Jan 05;11
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6