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protein coding gene - gem8 (SPBC16H5.15) - SMN complex subunit Gem8

Gene summary

Standard name
gem8
Systematic ID
SPBC16H5.15
Product
SMN complex subunit Gem8
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USY8
ORFeome ID
04/04H06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2290595..2291340 reverse strand

Annotation

GO biological process

GO:0000387 - spliceosomal snRNP assembly

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0032797 - SMN complex

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0003683 - abnormal spliceosomal complex assembly

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Genotypes:

FYPO:0007719 - abolished SMN complex assembly

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Genotypes:

FYPO:0004204 - decreased mature snRNA level

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Genotypes:

FYPO:0003029 - decreased mRNA splicing, via spliceosome

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002059 - inviable cell population

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Genotypes:

FYPO:0002411 - inviable curved elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF12720DUF3807DUF3807PFAM
PTHR40642YALI0F31295PDUF3807PANTHER
CoilCoilCOILS

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25274039 - A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.
Bayne EH et al. Genome Biol 2014;15(10):481
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33754639 - Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.
Veepaschit J et al. Nucleic Acids Res 2021 Jul 21;49(13):7207-7223
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81