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protein coding gene - mlh1 (SPBC1703.04) - MutL family protein Mlh1

Gene summary

Standard name
mlh1
Systematic ID
SPBC1703.04
Product
MutL family protein Mlh1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7W6
ORFeome ID
28/28C06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2921230..2923544 forward strand

Annotation

Disease association

MONDO:0005835 - Lynch syndrome

References:

MONDO:0007356 - Lynch syndrome 1

References:

MONDO:0012249 - Lynch syndrome 2

References:

MONDO:0010159 - mismatch repair cancer syndrome 1

References:

MONDO:0008018 - Muir-Torre syndrome

References:

GO biological process

GO:0061982 - meiosis I cell cycle process

References:

GO:0006298 - mismatch repair

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0044732 - mitotic spindle pole body

References:

GO:0032389 - MutLalpha complex

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0140664 - ATP-dependent DNA damage sensor activity

References:

GO:0030983 - mismatched DNA binding

References:

Multi-locus phenotype

FYPO:0004993 - normal spore germination frequency

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

References:

Genotypes:

FYPO:0004557 - increased vegetative cell population growth

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0006811 - normal gross chromosomal rearrangement frequency

References:

Genotypes:

FYPO:0004993 - normal spore germination frequency

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0002226 - non-consensus branch site

Protein features

IDNameInterPro nameDB name
PF01119DNA_mis_repairDNA_mismatch_S5_2-likePfam
PF13589HATPase_c_3Pfam
PF16413Mlh1_CMlh1_CPfam
cd03483MutL_Trans_MLH1CDD
cd16926HATPase_MutL-MLH-PMS-likeCDD
PS00058DNA_MISMATCH_REPAIR_1DNA_mismatch_repair_CSPROSITE patterns
SM01340DNA_mis_repairDNA_mismatch_S5_2-likeSMART
G3DSA:3.30.230.10:FF:000014CATH-FunFam
G3DSA:3.30.565.10:FF:000109CATH-FunFam
G3DSA:3.30.230.10Ribsml_uS5_D2-typ_fold_subgrCATH-Gene3D
G3DSA:3.30.565.10HATPase_C_sfCATH-Gene3D
SSF54211Ribosomal_Su5_D2-typ_SFSUPERFAMILY
SSF55874HATPase_C_sfSUPERFAMILY
PTHR10073MutL/Mlh/Pms-likePANTHER
TIGR00585mutlMutL/Mlh/PMSNCBIFAM

Orthologs

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:32355220 - DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.
Onaka AT et al. Commun Biol 2020 Apr 30;3(1):202
PMID:20452294 - Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe.
Ramasubramanyan S et al. DNA Repair (Amst) 2010 Jul 01;9(7):777-84
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.
Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:12713814 - Different frameshift mutation spectra in non-repetitive DNA of MutSalpha- and MutLalpha-deficient fission yeast cells.
Marti TM et al. DNA Repair (Amst) 2003 May 13;2(5):571-80
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000002 - Comments
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:31712578 - DNA sequence differences are determinants of meiotic recombination outcome.
Brown SD et al. Sci Rep 2019 Nov 11;9(1):16446