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protein coding gene - pof10 (SPBC1703.06) - F-box/WD repeat protein Pof10

Gene summary

Standard name
pof10
Systematic ID
SPBC1703.06
Product
F-box/WD repeat protein Pof10
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7W4
ORFeome ID
27/27F04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2925514..2927790 forward strand

Annotation

Disease association

MONDO:0859280 - developmental delay, hypotonia, and impaired language

References:

GO biological process

GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0000151 - ubiquitin ligase complex

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GO molecular function

GO:0005515 - protein binding

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GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

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Modification

MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111823 - F-box protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0004494 - inviable branched, swollen, elongated vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0007931 - sensitive to egtazic acid

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0002546 - sensitive to trichostatin A

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Genotypes:

FYPO:0002215 - viable curved elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0000070 - gene structure updated

Protein features

IDNameInterPro nameDB name
PF00400WD40WD40_rptPfam
PF12937F-box-likeF-box_domPfam
cd09917F-box_SFCDD
PS50082WD_REPEATS_2WD40_rptPROSITE profiles
PS50181FBOXF-box_domPROSITE profiles
PS50330UIMUIM_domPROSITE profiles
SM00256FBOXF-box_domSMART
G3DSA:1.20.1280.50CATH-Gene3D
G3DSA:2.130.10.10WD40/YVTN_repeat-like_dom_sfCATH-Gene3D
SSF50978WD40_repeat_dom_sfSUPERFAMILY
SSF81383F-box-like_dom_sfSUPERFAMILY
PTHR12874PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:19748355 - F-box-directed CRL complex assembly and regulation by the CSN and CAND1.
Schmidt MW et al. Mol Cell 2009 Sep 11;35(5):586-97
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.
Wu S et al. Nat Commun 2013;4:1642
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.
Lehmann A et al. Genes Cells 2004 May;9(5):367-82
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:17016471 - Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.
Tafforeau L et al. EMBO J 2006 Oct 04;25(19):4547-56
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:11820777 - Isolation and characterization of a novel F-box protein Pof10 in fission yeast.
Ikebe C et al. Biochem Biophys Res Commun 2002 Feb 08;290(5):1399-407
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83