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protein coding gene - vps33 (SPBC1703.15c) - HOPS/CORVET complex subunit, vacuolar sorting protein Vps33

Gene summary

Standard name
vps33
Systematic ID
SPBC1703.15c
Product
HOPS/CORVET complex subunit, vacuolar sorting protein Vps33
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC2A9.01c
UniProt ID
Q9P7V6
ORFeome ID
37/37A05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2944868..2947137 reverse strand

Annotation

Disease association

MONDO:0008822 - arthrogryposis, renal dysfunction, and cholestasis 1

References:

MONDO:0017123 - arthrogryposis-renal dysfunction-cholestasis syndrome

References:

MONDO:0031040 - cholestasis, progressive familial intrahepatic, 12

References:

MONDO:0859278 - keratoderma-ichthyosis-deafness syndrome, autosomal recessive

References:

MONDO:0015012 - mucopolysaccharidosis-plus syndrome

References:

GO biological process

GO:0006886 - intracellular protein transport

References:

GO:0045324 - late endosome to vacuole transport

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GO:0042144 - vacuole fusion, non-autophagic

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GO cellular component

GO:0033263 - CORVET complex

References:

GO:0000324 - fungal-type vacuole

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GO:1902500 - vacuolar HOPS complex

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GO molecular function

GO:7770062 - vesicle membrane tethering activity

References:

Modification

MOD:00046 - O-phospho-L-serine

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004483 - abnormal vacuole fusion during cellular hypotonic response

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Genotypes:

FYPO:0000583 - abolished sporulation

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Genotypes:

FYPO:0005547 - decreased protein targeting to vacuole, with protein secreted

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0007286 - normal protein localization to late endosome membrane

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Genotypes:

FYPO:0000076 - resistance to nystatin

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Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0000098 - sensitive to calcium

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0000281 - small vacuoles present in increased numbers during vegetative growth

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Genotypes:

FYPO:0000369 - vacuoles absent

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00995Sec1Sec1-likePfam
G3DSA:1.25.40.850:FF:000001CATH-FunFam
G3DSA:1.25.40.850VPS33_dom3bCATH-Gene3D
G3DSA:3.40.50.1910Sec1-like_dom2CATH-Gene3D
G3DSA:3.40.50.2060Sec-1-like_dom1CATH-Gene3D
G3DSA:3.90.830.10Sec-1-like_dom3aCATH-Gene3D
SSF56815Sec1-like_sfSUPERFAMILY
PTHR11679Sec1-likePANTHER

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:12868054 - Characterization of vps33+, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pombe.
Iwaki T et al. Yeast 2003 Jul 30;20(10):845-55
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21757403 - Schizosaccharomyces pombe Pep12p is required for vacuolar protein transport and vacuolar homotypic fusion.
Hosomi A et al. J Biosci Bioeng 2011 Oct;112(4):309-14
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PB_REF:0000003 - Disease Association Curation
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
GO_REF:0000033 - Annotation inferences using phylogenetic trees