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protein coding gene - fzo1 (SPBC1706.03) - mitochondrial dynamin family fusion GTPase (mitofusin) Fzo1

Gene summary

Standard name
fzo1
Systematic ID
SPBC1706.03
Product
mitochondrial dynamin family fusion GTPase (mitofusin) Fzo1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC839.01
UniProt ID
Q9USY7
ORFeome ID
28/28B10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 594366..597186 forward strand

Annotation

Disease association

MONDO:0015626 - Charcot-Marie-Tooth disease

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MONDO:0012231 - Charcot-Marie-Tooth disease type 2A2

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MONDO:0010479 - Charcot-Marie-Tooth disease X-linked dominant 6

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MONDO:0014906 - Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b;

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MONDO:0007908 - multiple symmetric lipomatosis

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MONDO:0005071 - nervous system disorder

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MONDO:0011002 - neuropathy, hereditary motor and sensory, type 6A

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GO biological process

GO:1990626 - mitochondrial outer membrane fusion

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GO:0051646 - mitochondrion localization

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GO cellular component

GO:0005741 - mitochondrial outer membrane

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GO molecular function

GO:0005525 - GTP binding

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GO:0061791 - GTPase motor activity

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000013 - RNA level unchanged

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000141 - abnormal mitotic sister chromatid segregation

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Genotypes:

FYPO:0000177 - abnormal mitotic spindle assembly

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Genotypes:

FYPO:0003914 - increased protein level in stationary phase

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0002401 - microtubule bundles present in increased numbers

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Genotypes:

FYPO:0000056 - mitochondria fused

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Genotypes:

FYPO:0007208 - normal microtubule bundle length during mitotic interphase

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0001510 - viable vegetative cell, abnormal cell shape, normal cell size

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00350Dynamin_NDynamin_NPfam
PS51718G_DYNAMIN_2G_DYNAMIN_domPROSITE profiles
G3DSA:3.40.50.300:FF:000638CATH-FunFam
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR10465Mitofusin_famPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:35075549 - Schizosaccharomyces pombe Fzo1 is subjected to the ubiquitin-proteasome-mediated degradation during the stationary phase.
Ahmad F et al. Int Microbiol 2022 May;25(2):397-404
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000002 - Comments
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000003 - Disease Association Curation
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23293578 - Molecular genetics of charcot-marie-tooth disease: from genes to genomes.
Azzedine H et al. Mol Syndromol 2012 Nov;3(5):204-14
PMID:30658998 - A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Delerue T et al. Dis Model Mech 2019 Feb 07;12(2)
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:33125774 - dnm1 deletion blocks mitochondrial fragmentation in Δfzo1 cells.
Yang Y et al. Yeast 2021 Mar;38(3):197-205
PMID:35658118 - The acyl-CoA-binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation.
He J et al. FEBS Lett 2022 Jul;596(14):1795-1808
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:33125111 - Loss of FZO1 gene results in changes of cell dynamics in fission yeast.
Yuan R et al. Int J Mol Med 2020 Dec;46(6):2194-2206
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:34310050 - Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast.
Dong F et al. FEBS J 2022 Jan;289(1):262-278