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protein coding gene - cyp3 (SPBC1709.04c) - cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp3

Gene summary

Standard name
cyp3
Systematic ID
SPBC1709.04c
Product
cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74729
ORFeome ID
11/11A01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1103600..1104669 reverse strand

Annotation

PBO:0000929 - 5.2.1.8

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO:0006457 - protein folding

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

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GO molecular function

GO:0003755 - peptidyl-prolyl cis-trans isomerase activity

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0006012 - elongated cell with abolished shmoo formation

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Genotypes:

FYPO:0003882 - increased cyclosporin A binding

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Genotypes:

FYPO:0003883 - increased sanglifehrin A binding

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0009066 - resistance to amorolfine

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001103 - resistance to hydrogen peroxide

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007808 - resistance to valproic acid

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00160Pro_isomeraseCyclophilin-type_PPIase_domPFAM
cd01926cyclophilin_ABH_likeCDD
PS00170CSA_PPIASE_1Cyclophilin-type_PPIase_CSPROSITE_PATTERNS
PS50072CSA_PPIASE_2Cyclophilin-type_PPIase_domPROSITE_PROFILES
PR00153CSAPPISMRASECyclophilin-type_PPIase_domPRINTS
G3DSA:2.40.100.10:FF:000035FUNFAM
SSF50891Cyclophilin-likeCyclophilin-like_dom_sfSUPERFAMILY
G3DSA:2.40.100.10Cyclophilin-like_dom_sfGENE3D
PTHR11071PEPTIDYL-PROLYL CIS-TRANS ISOMERASEPANTHER
PIRSF001467Peptidylpro_ismrseCyclophilin-type_PPIasePIRSF

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:12651004 - Identification and characterisation of Schizosaccharomyces pombe cyclophilin 3, a cyclosporin A insensitive orthologue of human USA-CyP.
Pemberton TJ et al. J Chromatogr B Analyt Technol Biomed Life Sci 2003 Mar 25;786(1-2):81-91
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:14644438 - Cyclophilin sensitivity to sanglifehrin A can be correlated to the same specific tryptophan residue as cyclosporin A.
Pemberton TJ et al. FEBS Lett 2003 Dec 04;555(2):335-40