protein coding gene - cft1 (SPBC1709.08) - mRNA cleavage and polyadenylation specificity factor complex, WD repeat protein Cft1

Gene summary

Standard name

cft1

Systematic ID

SPBC1709.08

Product

mRNA cleavage and polyadenylation specificity factor complex, WD repeat protein Cft1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74733

ORFeome ID

39/39E05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1113270..1118228 forward strand

Annotation

Protein features

Orthologs

• CPSF1 (HGNC:2324) Homo sapiens
• cft1 (SJAG_03233) Schizosaccharomyces japonicus
• CFT1 (YDR301W) Saccharomyces cerevisiae

References / Literature

PMID:27401558 - The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection.

Lemay JF et al. Genes Dev 2016 Jul 01;30(13):1558-72

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:35012333 - Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.

Schwer B et al. mBio 2022 Feb 22;13(1):e0347621

PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.

Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:15743824 - Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects.

Wang SW et al. Mol Cell Biol 2005 Mar;25(6):2288-96

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:31615333 - Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.

Nakazawa N et al. Open Biol 2019 Oct 31;9(10):190125

PMID:14617822 - A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Roguev A et al. Mol Cell Proteomics 2004 Feb;3(2):125-32

PMID:24210919 - Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Lee NN et al. Cell 2013 Nov 21;155(5):1061-74

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:29899453 - A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II.

Parua PK et al. Nature 2018 Jun;558(7710):460-464

PMID:31269446 - CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV et al. Cell Rep 2019 Jul 02;28(1):267-281.e5

PMID:33711009 - Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.

Benjamin B et al. PLoS Genet 2021 Mar;17(3):e1009452

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:28367989 - The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Wittmann S et al. Nat Commun 2017 Apr 03;8:14861

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053