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protein coding gene - met7 (SPBC1709.17) - folylpolyglutamate synthase Met7

Gene summary

Standard name
met7
Systematic ID
SPBC1709.17
Product
folylpolyglutamate synthase Met7
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74742
ORFeome ID
26/26C12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1132227..1134168 forward strand

Annotation

GO biological process

GO:0006730 - one-carbon metabolic process

References:

GO:0046901 - tetrahydrofolylpolyglutamate biosynthetic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004326 - tetrahydrofolylpolyglutamate synthase activity

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

Protein features

IDNameInterPro nameDB name
PS01012FOLYLPOLYGLU_SYNT_2Folylpolyglutamate_synth_CSPROSITE_PATTERNS
PS01011FOLYLPOLYGLU_SYNT_1Folylpolyglutamate_synth_CSPROSITE_PATTERNS
G3DSA:3.40.1190.10:FF:000009FUNFAM
SSF53244MurD-like peptide ligases, peptide-binding domainMur_ligase_C_dom_sfSUPERFAMILY
SSF53623MurD-like peptide ligases, catalytic domainMur-like_cat_sfSUPERFAMILY
G3DSA:3.90.190.20Mur_ligase_C_dom_sfGENE3D
G3DSA:3.40.1190.10Mur-like_cat_sfGENE3D
PTHR11136FOLYLPOLYGLUTAMATE SYNTHASE-RELATEDFolylpolyglutamate_synthPANTHER
PIRSF038895FPGSFolylpolyglutamate_synth_eukPIRSF
TIGR01499folCFolylpolyglutamate_synthNCBIFAM

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:10759889 - Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Ding DQ et al. Genes Cells 2000 Mar;5(3):169-90
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000002 - Comments
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7