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protein coding gene - nfu1 (SPBC1709.19c) - mitochondrial [4Fe-4S] cluster transfer protein Nfu1

Gene summary

Standard name
nfu1
Systematic ID
SPBC1709.19c
Product
mitochondrial [4Fe-4S] cluster transfer protein Nfu1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC409.02c
UniProt ID
Q9UUB8
ORFeome ID
09/09G07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1136612..1137755 reverse strand

Annotation

Disease association

MONDO:0011582 - multiple mitochondrial dysfunctions syndrome 1

References:

MONDO:0975796 - spastic paraplegia 93, autosomal recessive

References:

GO biological process

GO:0016226 - iron-sulfur cluster assembly

References:

GO:0051604 - protein maturation

References:

GO cellular component

GO:0120510 - mitochondrial [4Fe-4S] assembly complex

References:

GO:0005759 - mitochondrial matrix

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0051539 - 4 iron, 4 sulfur cluster binding

References:

GO:0005506 - iron ion binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0009070 - resistance to itraconazole

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000022 - shmoo with long tip

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01106NifUNIF_FeS_clus_asmbl_NifU_CPfam
PF08712Nfu_NNfu/NifU_NPfam
SM00932Nfu_NNfu/NifU_NSMART
G3DSA:3.30.1370.70:FF:000001CATH-FunFam
G3DSA:3.30.300.130:FF:000001CATH-FunFam
G3DSA:3.30.1370.70Nfu/NifU_N_sfCATH-Gene3D
G3DSA:3.30.300.130FSCA_dom_sfCATH-Gene3D
SSF110836Nfu/NifU_N_sfSUPERFAMILY
SSF117916FSCA_dom_sfSUPERFAMILY
PTHR11178PANTHER
PIRSF036773HIRIP5NFU1-likePIRSF

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:34660592 - Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.
Shi R et al. Front Cell Dev Biol 2021;9:735678
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)