protein coding gene - prp16 (SPBC1711.17) - ATP-dependent RNA helicase, splicosomal Prp16

Gene summary

Standard name

prp16

Systematic ID

SPBC1711.17

Product

ATP-dependent RNA helicase, splicosomal Prp16

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPBC17G9.01, prp14

UniProt ID

Q9P774

ORFeome ID

48/48D04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2166225..2169933 forward strand

Annotation

Protein features

Orthologs

• DHX38 (HGNC:17211) Homo sapiens
• prp16 (SJAG_01152) Schizosaccharomyces japonicus
• PRP16 (YKR086W) Saccharomyces cerevisiae

References / Literature

PB_REF:0000003 - Disease Association Curation

PMID:26682798 - The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.

Aronica L et al. Nucleic Acids Res 2016 Feb 29;44(4):1703-17

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:30810475 - Early splicing functions of fission yeast Prp16 and its unexpected requirement for gene Silencing is governed by intronic features.

Vijayakumari D et al. RNA Biol 2019 Jun;16(6):754-769

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:9003295 - Isolation of novel pre-mRNA splicing mutants of Schizosaccharomyces pombe.

Urushiyama S et al. Mol Gen Genet 1996 Nov 27;253(1-2):118-27

PMID:28231281 - The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin.

Mutazono M et al. PLoS Genet 2017 Feb;13(2):e1006606

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Ren L et al. PLoS One 2011 Feb 28;6(2):e16719

PMID:20018856 - Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres.

Chinen M et al. J Biol Chem 2010 Feb 19;285(8):5630-8

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

GO_REF:0000002 - Comments

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:24014766 - Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.

Livesay SB et al. Eukaryot Cell 2013 Nov;12(11):1472-89

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.

Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701

PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.

Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101

PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902

PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .

Budden AM et al. Elife 2023 Aug 24;12