protein coding gene - pop1 (SPBC1718.01) - cullin 1 adaptor protein Pop1

Gene summary

Standard name

pop1

Systematic ID

SPBC1718.01

Product

cullin 1 adaptor protein Pop1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ste16, SPBC2G2.18

UniProt ID

P87060

ORFeome ID

33/33G07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3469128..3471885 forward strand

Annotation

Protein features

Orthologs

• FBXO24 (HGNC:13595) Homo sapiens
• FBXW2 (HGNC:13608) Homo sapiens
• FBXW7 (HGNC:16712) Homo sapiens
• pop1 (SJAG_02651) Schizosaccharomyces japonicus
• CDC4 (YFL009W) Saccharomyces cerevisiae

References / Literature

PMID:9203581 - Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18.

Kominami K et al. Genes Dev 1997 Jun 15;11(12):1548-60

PMID:10880460 - Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

Osaka F et al. EMBO J 2000 Jul 03;19(13):3475-84

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.

Wu S et al. Nat Commun 2013;4:1642

PMID:34608864 - DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.

Aricthota S et al. Elife 2021 Oct 05;10

PMID:20547592 - Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.

Wen WL et al. Nucleic Acids Res 2010 Oct;38(19):6555-66

PMID:14970237 - Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2.

Yamano H et al. J Biol Chem 2004 Apr 30;279(18):18974-80

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70

PMID:17531813 - Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.

Hermand D et al. Mol Cell 2007 May 25;26(4):553-63

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:9990507 - Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase.

Kominami K et al. Genes Cells 1998 Nov;3(11):721-35

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:26147350 - The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage.

Uchiyama M et al. PLoS One 2015;10(7):e0130000

PMID:9472077 - The Ste16 WD-repeat protein regulates cell-cycle progression under starvation through the Rum1 protein in Schizosaccharomyces pombe.

Maekawa H et al. Curr Genet 1998 Jan;33(1):29-37

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:12668659 - An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation.

Tasto JJ et al. J Cell Biol 2003 Mar 31;160(7):1093-103

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Lehmann A et al. Genes Cells 2004 May;9(5):367-82

PMID:12167173 - Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p.

Seibert V et al. BMC Biochem 2002 Aug 07;3:22

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:10209119 - F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p.

Wolf DA et al. Curr Biol 1999 Apr 08;9(7):373-6

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12