protein coding gene - hop1 (SPBC1718.02) - linear element associated protein Hop1

Gene summary

Standard name

hop1

Systematic ID

SPBC1718.02

Product

linear element associated protein Hop1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9P7P2

ORFeome ID

26/26C01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3472319..3474169 forward strand

Annotation

Protein features

Orthologs

• HORMAD1 (HGNC:25245) Homo sapiens
• HORMAD2 (HGNC:28383) Homo sapiens
• hop1 (SJAG_02652) Schizosaccharomyces japonicus
• HOP1 (YIL072W) Saccharomyces cerevisiae

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.

Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.

Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:19756689 - SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.

Spirek M et al. Chromosoma 2010 Feb;119(1):59-72

PMID:22362333 - Mug20, a novel protein associated with linear elements in fission yeast meiosis.

Estreicher A et al. Curr Genet 2012 Apr;58(2):119-27

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:19911044 - Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.

Rothenberg M et al. PLoS Genet 2009 Nov;5(11):e1000722

PMID:20123974 - Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe.

Latypov V et al. Mol Cell Biol 2010 Apr;30(7):1570-81

PMID:30289413 - Structural insights into the recognition of phosphorylated Hop1 by Mek1.

Xie C et al. Acta Crystallogr D Struct Biol 2018 Oct 01;74(Pt 10):1027-1038

PMID:33825974 - Linear elements are stable structures along the chromosome axis in fission yeast meiosis.

Ding DQ et al. Chromosoma 2021 Sep;130(2-3):149-162

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

PMID:15226405 - S. pombe meiotic linear elements contain proteins related to synaptonemal complex components.

Lorenz A et al. J Cell Sci 2004 Jul 01;117(Pt 15):3343-51

PMID:31665745 - Conserved HORMA domain-containing protein Hop1 stabilizes interaction between proteins of meiotic DNA break hotspots and chromosome axis.

Kariyazono R et al. Nucleic Acids Res 2019 Nov 04;47(19):10166-10180

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:16532353 - Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.

Lorenz A et al. Chromosoma 2006 Aug;115(4):330-40

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:29550859 - Genetic interactions between the chromosome axis-associated protein Hop1 and homologous recombination determinants in Schizosaccharomyces pombe.

Brown SD et al. Curr Genet 2018 Oct;64(5):1089-1104

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12