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protein coding gene - fol1 (SPBC1734.03) - trifunctional dihydropteroate synthase/ 2-amino-4-hydroxy-6-hydro xymethyldihydropteridine diphosphokinase/ dihydroneopterin aldolase Fol1

Gene summary

Standard name
fol1
Systematic ID
SPBC1734.03
Product
trifunctional dihydropteroate synthase/ 2-amino-4-hydroxy-6-hydro xymethyldihydropteridine diphosphokinase/ dihydroneopterin aldolase Fol1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC337.19
UniProt ID
Q4LB35
ORFeome ID
37/37C06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1064158..1066654 forward strand

Annotation

PBO:0003453 - 2.5.1.15

PBO:0003454 - 2.7.6.3

PBO:0003455 - 4.1.2.25

GO biological process

GO:0046656 - folic acid biosynthetic process

References:

GO:0046654 - tetrahydrofolate biosynthetic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005740 - mitochondrial envelope

References:

GO molecular function

GO:0003848 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity

References:

GO:0004150 - dihydroneopterin aldolase activity

References:

GO:0004156 - dihydropteroate synthase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00696 - phosphorylated residue

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00809Pterin_bindPterin-binding_domPfam
PF01288HPPKHppkPfam
PF02152FolBFolB_domPfam
cd00483HPPKHppkCDD
cd00534DHNA_DHNTPEFolB_domCDD
cd00739DHPSDHP_synth_domCDD
PS00793DHPS_2Pterin-binding_domPROSITE patterns
PS50972PTERIN_BINDINGPterin-binding_domPROSITE profiles
SM00905FolBFolB_domSMART
G3DSA:3.20.20.20:FF:000006CATH-FunFam
G3DSA:3.20.20.20Dihydropteroate_synth-like_sfCATH-Gene3D
G3DSA:3.30.1130.10GTP-CH-I_C/QueFCATH-Gene3D
G3DSA:3.30.70.560Hppk_sfCATH-Gene3D
SSF51717Dihydropteroate_synth-like_sfSUPERFAMILY
SSF55083Hppk_sfSUPERFAMILY
SSF55620SUPERFAMILY
PTHR20941DHP_synth-likePANTHER
PIRSF000741Folic_acid_synthFolic_acid_synthPIRSF
TIGR01496DHPSDHP_synth_domNCBIFAM
TIGR01498folKHppkNCBIFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87