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protein coding gene - hse1 (SPBC1734.08) - ESCRT 0 complex subunit, sorting receptor for ubiquitinated membrane proteins, Hse1

Gene summary

Standard name
hse1
Systematic ID
SPBC1734.08
Product
ESCRT 0 complex subunit, sorting receptor for ubiquitinated membrane proteins, Hse1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74749
ORFeome ID
32/32H12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1074379..1075953 forward strand

Annotation

GO biological process

GO:0031321 - ascospore-type prospore assembly

References:

GO:0010496 - intercellular transport

References:

GO:0045324 - late endosome to vacuole transport

References:

GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

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GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0033565 - ESCRT-0 complex

References:

GO:0000329 - fungal-type vacuole membrane

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GO:0005794 - Golgi apparatus

References:

GO:0005634 - nucleus

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GO:0005628 - prospore membrane

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GO molecular function

GO:0035091 - phosphatidylinositol binding

References:

GO:0043130 - ubiquitin binding

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001123 - elongated spore

References:

Genotypes:

FYPO:0004954 - excess prospore membrane present

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Genotypes:

FYPO:0002052 - normal sporulation frequency

References:

Genotypes:

Protein features

PBO:0111785 - ENTH/VHS domain protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0009097 - decreased cell population growth on xylose carbon source

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Genotypes:

FYPO:0009052 - increased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0000943 - normal spore morphology

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Genotypes:

FYPO:0002052 - normal sporulation frequency

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Genotypes:

FYPO:0009030 - resistance to amitrole

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009035 - resistance to formamide

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009067 - sensitive to amorolfine

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009084 - sensitive to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009090 - sensitive to sodium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001457 - sensitive to tunicamycin

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00018SH3_1SH3_domainPfam
PF00790VHSVHS_domPfam
PF03127GATGAT_domPfam
cd11805SH3_GRB2_like_CCDD
cd16978VHS_HSE1CDD
cd21386GAT_Hse1CDD
PS50002SH3SH3_domainPROSITE profiles
PS50179VHSVHS_domPROSITE profiles
PS50330UIMUIM_domPROSITE profiles
SM00288VHSVHS_domSMART
SM00326SH3SH3_domainSMART
PR00452SH3DOMAINSH3_domainPRINTS
PR00499P67PHOXPRINTS
G3DSA:1.25.40.90:FF:000009CATH-FunFam
G3DSA:2.30.30.40:FF:000072CATH-FunFam
G3DSA:1.20.5.1940CATH-Gene3D
G3DSA:1.25.40.90ENTH_VHSCATH-Gene3D
G3DSA:2.30.30.40CATH-Gene3D
SSF48464ENTH_VHSSUPERFAMILY
SSF50044SH3-like_dom_sfSUPERFAMILY
SSF89009SUPERFAMILY
PTHR45929STAMPANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar

Orthologs

References / Literature

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:34028542 - TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose.
Toyoda Y et al. J Cell Sci 2021 May 15;134(10)
PMID:17660439 - Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe.
Iwaki T et al. Microbiology (Reading) 2007 Aug;153(Pt 8):2753-2764
GO_REF:0000002 - Comments
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:17951524 - Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
Onishi M et al. Eukaryot Cell 2007 Dec;6(12):2343-53
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000117 - Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12