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protein coding gene - ipa1 (SPBC1734.10c) - cleavage and polyadenylation HECT-type ubiquitin-protein ligase E3 Ipa1

Gene summary

Standard name
ipa1
Systematic ID
SPBC1734.10c
Product
cleavage and polyadenylation HECT-type ubiquitin-protein ligase E3 Ipa1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74751
ORFeome ID
44/44G10
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1076179..1078918 reverse strand

Annotation

GO biological process

GO:0180010 - co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

References:

GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0000151 - ubiquitin ligase complex

References:

GO molecular function

GO:0030332 - cyclin binding

References:

GO:0031624 - ubiquitin conjugating enzyme binding

References:

GO:0061630 - ubiquitin protein ligase activity

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0001137 - ncRNA in intron

Protein features

IDNameInterPro nameDB name
PF09814HECT_2UBQ-conj_enz_E2-bd_protPfam
PTHR31531UBQ-conj_enz_E2-bd_protPANTHER

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323