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protein coding gene - suc1 (SPBC1734.14c) - cyclin-dependent protein kinase regulatory subunit Suc1

Gene summary

Standard name
suc1
Systematic ID
SPBC1734.14c
Product
cyclin-dependent protein kinase regulatory subunit Suc1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
p13
UniProt ID
P08463
ORFeome ID
39/39H05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1087538..1088832 reverse strand

Annotation

GO biological process

GO:0007346 - regulation of mitotic cell cycle

References:

GO:0023052 - signaling

References:

GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

References:

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0019005 - SCF ubiquitin ligase complex

References:

GO molecular function

GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity

References:

GO:0042393 - histone binding

References:

GO:0005515 - protein binding

References:

GO:0044877 - protein-containing complex binding

References:

GO:0043130 - ubiquitin binding

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0000681 - abnormal sporulation resulting in formation of two-spore ascus

References:

Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000023 - protein level constant

References:

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

References:

Genotypes:

FYPO:0000681 - abnormal sporulation resulting in formation of two-spore ascus

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002700 - increased protein kinase activity

References:

Genotypes:

FYPO:0000316 - inviable after spore germination

References:

Genotypes:

FYPO:0002429 - inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell size

References:

Genotypes:

FYPO:0002724 - inviable after spore germination, single or double cell division, elongated cell

References:

Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

References:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0003116 - sensitive to plumbagin

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

Subunit composition

PBO:0015212 - homomeric(2)

References:

PBO:0001467 - monomeric

References:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF01111CKSCyclin-dep_kinase_reg-subPfam
PS00944CKS_1Cyclin-dep_kinase_reg-subPROSITE patterns
PS00945CKS_2Cyclin-dep_kinase_reg-subPROSITE patterns
SM01084CKSCyclin-dep_kinase_reg-subSMART
PR00296CYCLINKINASECyclin-dep_kinase_reg-subPRINTS
G3DSA:3.30.170.10:FF:000002CATH-FunFam
G3DSA:3.30.170.10Cyclin-dep_kinase_reg-sub_sfCATH-Gene3D
SSF55637Cyclin-dep_kinase_reg-sub_sfSUPERFAMILY
PTHR23415PANTHER

Orthologs

References / Literature

PMID:8170927 - Mutational analysis supports a structural model for the cell cycle protein kinase p34.
Endicott JA et al. Protein Eng 1994 Feb;7(2):243-53
PMID:2245912 - stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.
Hudson JD et al. Genetics 1990 Oct;126(2):309-15
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:9211981 - Mitosis-specific phosphorylation of gar2, a fission yeast nucleolar protein structurally related to nucleolin.
Gulli MP et al. Chromosoma 1997 Jun;105(7-8):532-41
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:3010051 - The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function.
Hayles J et al. Mol Gen Genet 1986 Feb;202(2):291-3
PMID:7774573 - Dominant mutants identify new roles for p34cdc2 in mitosis.
Labib K et al. EMBO J 1995 May 15;14(10):2155-65
PMID:3297353 - Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+.
Draetta G et al. Cell 1987 Jul 17;50(2):319-25
PMID:8805536 - Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer.
Khazanovich N et al. Structure 1996 Mar 15;4(3):299-309
PMID:11812792 - Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate.
Odaert B et al. J Biol Chem 2002 Apr 05;277(14):12375-81
PMID:7479758 - Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch.
Bourne Y et al. Proc Natl Acad Sci U S A 1995 Oct 24;92(22):10232-6
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:8413179 - Genetic analysis of human p34CDC2 function in fission yeast.
MacNeill SA et al. Mol Gen Genet 1993 Sep;240(3):315-22
PMID:15843986 - Preliminary crystallographic analysis of the Cks protein p13(suc1P90AP92A) from Schizosacharromyces pombe.
Kelly JA et al. Eur Biophys J 2005 Jul;34(5):430-3
PMID:16453733 - suc1 is an essential gene involved in both the cell cycle and growth in fission yeast.
Hayles J et al. EMBO J 1986 Dec 01;5(12):3373-9
PMID:2665944 - Regulation of p34cdc2 protein kinase during mitosis.
Moreno S et al. Cell 1989 Jul 28;58(2):361-72
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:3322810 - p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.
Brizuela L et al. EMBO J 1987 Nov;6(11):3507-14
PMID:1944283 - Mutations at sites involved in Suc1 binding inactivate Cdc2.
Ducommun B et al. Mol Cell Biol 1991 Dec;11(12):6177-84
PMID:2569363 - The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization.
Booher RN et al. Cell 1989 Aug 11;58(3):485-97
PMID:7889931 - The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein.
Endicott JA et al. EMBO J 1995 Mar 01;14(5):1004-14
PMID:27736299 - A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.
Moris N et al. Cell Cycle 2016 Nov 16;15(22):3121-3130
PMID:1372994 - p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.
Parker LL et al. Proc Natl Acad Sci U S A 1992 Apr 01;89(7):2917-21
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:2894685 - Control over the onset of DNA synthesis in fission yeast.
Simanis V et al. Philos Trans R Soc Lond B Biol Sci 1987 Dec 15;317(1187):507-16
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23028742 - The natural anticancer agent plumbagin induces potent cytotoxicity in MCF-7 human breast cancer cells by inhibiting a PI-5 kinase for ROS generation.
Lee JH et al. PLoS One 2012;7(9):e45023
PMID:11434772 - Structural role of the proline residues of the beta-hinge region of p13suc1 as revealed by site-directed mutagenesis and fluorescence studies.
Simeoni F et al. Biochemistry 2001 Jul 10;40(27):8030-42
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:3031478 - Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe.
Hindley J et al. Mol Cell Biol 1987 Jan;7(1):504-11
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:12153042 - Assignment of the 1H, 13C and 15N resonances and secondary structure of the monomeric p13suc1 protein of Saccharomyces pombe.
Odaert B et al. J Biomol NMR 2002 Jun;23(2):155-6
PMID:1896017 - Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles.
MacNeill SA et al. Mol Gen Genet 1991 Sep;229(1):109-18
PMID:8910298 - Intrinsic fluorescence properties and structural analysis of p13(suc1) from Schizosaccharomyces pombe.
Neyroz P et al. J Biol Chem 1996 Nov 01;271(44):27249-58
PMID:9790601 - A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition.
Gould KL et al. Mol Gen Genet 1998 Sep;259(4):437-48
GO_REF:0000051 - S. pombe keyword mapping