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protein coding gene - SPBC1773.16c - DNA-binding transcription factor, zf-fungal binuclear cluster type

Gene summary

Systematic ID
SPBC1773.16c
Product
DNA-binding transcription factor, zf-fungal binuclear cluster type
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O94573
ORFeome ID
36/36D02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 317694..320565 reverse strand

Annotation

GO biological process

GO:0045944 - positive regulation of transcription by RNA polymerase II

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GO cellular component

GO:0000228 - nuclear chromosome

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GO:0005634 - nucleus

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GO molecular function

GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

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GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

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GO:0008270 - zinc ion binding

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Modification

MOD:00046 - O-phospho-L-serine

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Protein features

PBO:0111744 - zf-fungal Zn(2)-Cys(6) binuclear cluster domain

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000117 - abnormal septum assembly

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0001236 - normal growth on cycloheximide

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0001795 - normal growth on purvalanol A

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0006011 - shmoo formation at cell side

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF04082Fungal_transXnlR_reg_domPFAM
PF00172Zn_clusZn2Cys6_DnaBDPFAM
cd00067GAL4Zn2Cys6_DnaBDCDD
cd12148fungal_TF_MHRCDD
PS00463ZN2_CY6_FUNGAL_1Zn2Cys6_DnaBDPROSITE_PATTERNS
PS50048ZN2_CY6_FUNGAL_2Zn2Cys6_DnaBDPROSITE_PROFILES
SM00066gal4_2Zn2Cys6_DnaBDSMART
SM00906Fungal_trans_2XnlR_reg_domSMART
SSF57701Zn2/Cys6 DNA-binding domainZn2-C6_fun-type_DNA-bd_sfSUPERFAMILY
G3DSA:4.10.240.10Zn2-C6_fun-type_DNA-bd_sfGENE3D
PTHR46910TRANSCRIPTION FACTOR PDR1AtrR-likePANTHER
CoilCoilCOILS

References / Literature

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
GO_REF:0000036 - Manual annotations that require more than one source of functional data to support the assignment of the associated GO term
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83